Lipase-catalysed tandem Knoevenagel condensation and esterification with alcohol cosolvents

被引：70

作者：

Lai, Yi-Feng ^{[1
,2
]}

Zheng, Hui ^{[2
]}

Chai, She-Jie ^{[2
]}

Zhang, Peng-Fei ^{[1
,2
]}

Chen, Xin-Zhi ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Mat Chem & Chem Engn, Hangzhou 310027, Peoples R China

[2] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Zhejiang, Peoples R China

来源：

GREEN CHEMISTRY | 2010年 / 12卷 / 11期

基金：

中国国家自然科学基金;

关键词：

ENZYME PROMISCUITY;

D O I：

10.1039/c004547k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Six lipases were screened for their ability to catalyse the Knoevenagel condensation between benzaldehyde and methyl cyanoacetate. Lipase from porcine pancreas tolerated a variety of functional groups on the aromatic ring, produced the highest yields, and also catalysed transesterification of the product in the presence of an alcoholic cosolvent. We show that, in organic solvents, lipase from porcine pancreas has higher activity for this "promiscuous" reaction than for naturally occurring esterification catalysis.

引用

页码：1917 / 1918

页数：2

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