Quinazoline-Containing Indole Alkaloids from the Marine-Derived Fungus Aspergillus sp. HNMF114

被引：36
作者：
Kong, Fan-Dong [1 ]
Zhang, Sheng-Liang [2 ]
Zhou, Shuang-Qing [2 ]
Ma, Qing-Yun [1 ]
Xie, Qing-Yi [1 ]
Chen, Jin-Ping [1 ]
Li, Jiu-Hui [1 ]
Zhou, Li-Man [1 ]
Yuan, Jing-Zhe [1 ]
Hu, Zhong [3 ]
Dai, Hao-Fu [1 ]
Huang, Xiao-Long [2 ]
Zhao, You-Xing [1 ]
机构：
[1] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China
[2] Hainan Univ, Key Lab Trop Biol Resources, Minist Educ, Haikou 570228, Hainan, Peoples R China
[3] Shantou Univ, Dept Biol, Coll Sci, Shantou 515063, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 12期
关键词：
METABOLITES; INHIBITOR; WORM;
D O I：
10.1021/acs.jnatprod.9b00845
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Seven new quinazoline-containing indole alkaloids (17) named aspertoryadins A-G, along with nine known ones (8-16), were isolated from the marine -derived fungus Aspergillus sp. HNMF114 from the bivalve mollusk Sanguinolaria chinensis. The structures of the new compounds were elucidated from spectroscopic data, X-ray diffraction analysis, ECD spectra analysis, and ECD calculations. Compound 1 bears an aminosulfonyl group in the structure, which is rarely encountered in natural products. Compounds 6, 7, and 13 exhibited quorum sensing inhibitory activity against Chromobacterium violaceum CV026 with MIC values of 32, 32, and 16 mu g/well, respectively.
引用
收藏
页码：3456 / 3463
页数：8
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