N,N-Diethyl-3-methylbenzamide

被引：0

作者：

Albert-Soriano, Maria

Pastor, Isidro M. ^{[1
]}

机构：

[1] Univ Alicante, Organ Chem Dept, Ctra San Vicente del Raspeig S-N, Alicante 03690, Spain

来源：

MOLBANK | 2022年 / 2022卷 / 03期

关键词：

amide; copper; heterogeneous catalysis; metal-organic framework; oxidative coupling; AMIDE BOND FORMATION; C-H AMINATION; CARBOXYLIC-ACIDS; METAL-FREE; COPPER; AMIDATION; FORMAMIDES; CATALYST;

D O I：

10.3390/M1395

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The development of new techniques for the preparation of organic compounds is important, with catalytic processes being key to this innovation. The development of copper-based metal-organic frameworks to promote oxidative couplings has allowed the synthesis of amides in a very effective manner. This methodology has been successfully applied to the unique preparation of the bioactive compound N,N-diethyl-3-methylbenzamide, with excellent performance (>99% conversion and 95% yield of pure isolated product) on a preparative scale. The described procedure can be classified as an excellent synthesis (EcoScale) considering environmental and economic factors based on different "green metrics" (atom economy, reaction mass efficiency, materials recovery factor, stoichiometric factor, E-factor).

引用

页数：6

共 18 条

[1] 1,3-Bis(carboxymethyl)imidazolium Chloride as a Metal-Free and Recyclable Catalyst for the Synthesis of N-Allylanilines by Allylic Substitution of Alcohols [J].