Effect of High-Frequency Oscillatory Ventilation Combined With Pulmonary Surfactant in the Treatment of Acute Respiratory Distress Syndrome After Cardiac Surgery: A Prospective Randomised Controlled Trial

被引:4
作者
Zheng, Yi-Rong [1 ,2 ,3 ,4 ]
Lei, Yu-Qing [1 ,2 ,3 ,4 ]
Liu, Jian-Feng [1 ,2 ,3 ,4 ]
Wu, Hong-Lin [1 ,2 ,3 ,4 ]
Xu, Ning [1 ,2 ,3 ,4 ]
Huang, Shu-Ting [1 ,2 ,3 ,4 ]
Cao, Hua [1 ,2 ,3 ,4 ]
Chen, Qiang [1 ,2 ,3 ,4 ]
机构
[1] Shanghai Childrens Med Ctr, Dept Cardiac Surg, Fujian Branch, Fuzhou, Peoples R China
[2] Fujian Childrens Hosp, Fuzhou, Peoples R China
[3] Fujian Med Univ, Fujian Matern & Child Hlth Hosp, Affiliated Hosp, Fuzhou, Peoples R China
[4] Fujian Matern & Child Hlth Hosp, Fujian Key Lab Women & Childrens Crit Dis Res, Fuzhou, Peoples R China
来源
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 8卷
关键词
high-frequency oscillatory ventilation; pulmonary surfactant; acute respiratory distress syndrome; congenital heart surgery; postoperative care; ACUTE LUNG INJURY; CONVENTIONAL VENTILATION; CHILDREN; DEFINITION; INFANTS;
D O I
10.3389/fcvm.2021.675213
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: This study aimed to evaluate the effects of pulmonary surfactant (PS) combined with high-frequency oscillatory ventilation (HFOV) or conventional mechanical ventilation (CMV) in infants with acute respiratory distress syndrome (ARDS) after congenital cardiac surgery. Methods: A total of 61 infants with ARDS were eligible and were randomised to the CMV + PS group (n = 30) or the HFOV + PS group (n = 31) between January 2020 and December 2020. The primary outcomes were the changes in arterial blood gas parameters. The duration of mechanical ventilation, length of hospitalisation and the incidence of complications were considered secondary outcomes. Results: A total of 61 infants completed the study. In the HFOV + PS group, the blood gas analysis results were significantly improved (P < 0.05), while the duration of mechanical ventilation and length of hospitalisation were shorter than the CMV + PS group (P < 0.05). However, the incidence of complications was not different between the two groups (P > 0.05). Conclusions: Compared with the CMV + PS group, the HFOV + PS group showed significantly improved ABG variables and had a shortened length of hospitalisation and mechanical ventilation in infants with ARDS after cardiac surgery.
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页数:7
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