Application of α-amino acids for the transition-metal-free synthesis of pyrrolo[1,2-a]quinoxalines

被引：34

作者：

Liu, Huanhuan ^{[1
]}

Zhou, Feiyu ^{[1
]}

Luo, Wen ^{[1
]}

Chen, Yuxin ^{[1
]}

Zhang, Chenyang ^{[1
]}

Ma, Chen ^{[1
,2
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China

[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 34期

基金：

美国国家科学基金会;

关键词：

IN-VITRO EVALUATION; DECARBOXYLATIVE AMINATION; BIOLOGICAL EVALUATION; DERIVATIVES; CONSTRUCTION; INHIBITORS; BEHAVIOR;

D O I：

10.1039/c7ob01688c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical and concise protocol for the efficient synthesis of pyrrolo[1,2-a] quinoxalines from readily available a-amino acids and 2-(1H-pyrrol-1-yl) anilines under transition metal-free conditions has been established. This protocol, which includes the formation of new C-C and C-N bonds, features a wide substrate scope with a broad range of functional group tolerance.

引用

页码：7157 / 7164

页数：8

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