共 52 条
[51]
2008, NCT00450814 VACCINE
[52]
2008, NCT00390299 VIRAL TH
Therapeutic Potential of Oncolytic Measles Virus: Promises and Challenges
被引：49
作者：
Galanis, E.
[1
,2
]
机构：
[1] Mayo Clin, Dept Oncol, Rochester, MN 55905 USA
[2] Mayo Clin, Dept Mol Med, Rochester, MN USA
关键词：
SODIUM-IODIDE SYMPORTER;
OVARIAN-CANCER;
CARCINOEMBRYONIC ANTIGEN;
GLIOBLASTOMA-MULTIFORME;
CELLULAR RECEPTOR;
PROSTATE-CANCER;
VACCINE STRAIN;
VIROTHERAPY;
GLIOMAS;
TUMOR;
D O I：
10.1038/clpt.2010.211
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Measles virus (MV) is a negative-strand RNA virus (paramyxovirus) with oncolytic properties. The significant preclinical activity of MV vaccine strains against a variety of tumor models, their potent bystander effect, their selectivity against tumor cells, and their ability to retain their oncolytic properties when engineered and retargeted makes them a promising oncolytic platform. In this article, we review potential applications and challenges associated with use of MV strains as cancer therapeutics.
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页码：620 / 625
页数：6
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