Early histological changes of bronchopulmonary dysplasia and pulmonary hypertension may precede clinical diagnosis in preterm infants*

被引：6
作者：
Stone, Amelia [2 ,4 ,5 ,7 ]
Poulik, Janet [3 ,5 ]
Koussa, Sara [2 ,5 ]
Xin, Yuemin [2 ,5 ]
Sharma, Amit [1 ,2 ,5 ]
Sood, Beena G. [1 ,2 ,5 ,6 ]
机构：
[1] Hutzel Womens Hosp, Childrens Hosp Michigan, Div Neonatal Perinatal Med, Detroit, MI USA
[2] Childrens Hosp Michigan, Hutzel Womens Hosp, Dept Pediat, Div Neonatal Perinatal Med, Detroit, MI USA
[3] Childrens Hosp Michigan, Hutzel Womens Hosp, Dept Pediat Pathol, Div Neonatal Perinatal Med, Detroit, MI USA
[4] Northwestern Univ, Dept Pediat, Chicago, IL USA
[5] Wayne State Univ, Sch Med, Detroit, MI USA
[6] Wayne State Univ, Dept Pediat, 340 E Canfield, Detroit, MI 48201 USA
[7] Northwestern Univ, Pediat, Chicago, IL USA
来源：
EARLY HUMAN DEVELOPMENT | 2022年 / 171卷
关键词：
Bronchopulmonarydysplasia; BPD; Pulmonaryhypertension; PH; Histology; Histological; Premature; Extremelypremature; Autopsy; Postmortem; Clinicaldefinition; OUTCOMES;
D O I：
10.1016/j.earlhumdev.2022.105612
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Bronchopulmonary Dysplasia (BPD), the commonest complication of prematurity, is defined by treatment with oxygen for >= 28 days. Pulmonary hypertension (PH) often coexists with BPD and is associated with increased mortality. In 42 autopsies, histological changes of BPD and PH were demonstrated in 25 % and 65 % respectively of preterm infants <28 days of age, highlighting the need for early diagnosis and treatment.
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页数：4
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