The Role of Betaine in Patients With Chronic Kidney Disease: a Narrative Review

被引：17

作者：

Alvarenga, Livia ^{[1
]}

Ferreira, Maira S. ^{[2
]}

Kemp, Julie A. ^{[3
]}

Mafra, Denise ^{[1
,4
]}

机构：

[1] Fed Fluminense Univ, Post Grad Program Med Sci, Unidade Pesquisa Clin, UFF, Rua Marques Parana 303, Niteroi, RJ, Brazil

[2] Univ Campinas UNICAMP, Fac Appl Sci State, Post Grad Program Sci Nutr Sports & Metab, Limeira, SP, Brazil

[3] Fed Fluminense Univ UFF, Post Grad Program Cardiovasc Sci, Niteroi, RJ, Brazil

[4] Fed Univ Rio de Janeiro UFRJ, Grad Program Biol Sci Physiol, Rio De Janeiro, RJ, Brazil

来源：

CURRENT NUTRITION REPORTS | 2022年 / 11卷 / 03期

关键词：

Betaine; Chronic kidney disease; Inflammation; Methyl donor; Oxidative stress; HEPATIC LIPID-ACCUMULATION; FACTOR-KAPPA-B; OXIDATIVE STRESS; GLYCINE BETAINE; SUPPLEMENTATION PROTECTS; PLASMA HOMOCYSTEINE; RENAL INJURY; CHOLINE; LIVER; METABOLISM;

D O I：

10.1007/s13668-022-00426-z

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Purpose of Review This narrative review aimed to explore the functions of betaine and discuss its role in patients with chronic kidney disease (CKD). Recent Findings Some studies on CKD animal models have shown the benefits of betaine supplementation, including decreased kidney damage, antioxidant recovery status, and decreased inflammation. Summary Betaine (N-trimethylglycine) is an N-trimethylated amino acid with an essential regulatory osmotic function. Moreover, it is a methyl donor and has anti-inflammatory and antioxidant properties. Additionally, betaine has positive effects on intestinal health by regulating the osmolality and gut microbiota. Due to these crucial functions, betaine has been studied in several diseases, including CKD, in which betaine plasma levels decline with the progression of the disease. Low betaine levels are linked to increased kidney damage, inflammation, oxidative stress, and intestinal dysbiosis. Furthermore, betaine is considered an essential metabolite for identifying CKD stages.

引用

页码：395 / 406

页数：12

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