Triglyceride glucose index is an independent predictor for the progression of coronary artery calcification in the absence of heavy coronary artery calcification at baseline

被引：135

作者：

Won, Ki-Bum ^{[1
,2
]}

Park, Eun Ji ^{[3
]}

Han, Donghee ^{[2
,4
,5
]}

Lee, Ji Hyun ^{[6
]}

Choi, Su-Yeon ^{[7
]}

Chun, Eun Ju ^{[8
]}

Park, Sung Hak ^{[9
]}

Han, Hae-Won ^{[10
]}

Sung, Jidong ^{[11
]}

Jung, Hae Ok ^{[12
]}

Chang, Hyuk-Jae ^{[2
,13
]}

机构：

[1] Univ Ulsan, Ulsan Univ Hosp, Div Cardiol, Coll Med, Ulsan, South Korea

[2] Yonsei Univ, Yonsei Univ Hlth Syst, Severance Cardiovasc Hosp, Div Cardiol,Coll Med, Seoul, South Korea

[3] Ulsan Univ Hosp, Med Informat Ctr, Ulsan, South Korea

[4] New York Presbyterian Hosp, Div Cardiol, New York, NY USA

[5] Weill Cornell Med Coll, New York, NY USA

[6] Myongji Hosp, Div Cardiol, Ilsan, South Korea

[7] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Div Cardiol, Seoul, South Korea

[8] Seoul Natl Univ, Div Radiol, Bundang Hosp, Seongnam, South Korea

[9] Gangnam Heartscan Clin, Div Radiol, Seoul, South Korea

[10] Gangnam Heartscan Clin, Dept Internal Med, Seoul, South Korea

[11] Samsung Med Ctr, Heart Stroke & Vasc Inst, Div Cardiol, Seoul, South Korea

[12] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Div Cardiol, Seoul, South Korea

[13] Yonsei Univ, Yonsei Cedars Sinai Integrat Cardiovasc Imaging R, Severance Cardiovasc Hosp, Yonsei Univ Hlth Syst,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea

来源：

CARDIOVASCULAR DIABETOLOGY | 2020年 / 19卷 / 01期

关键词：

Triglyceride glucose index; Insulin resistance; Coronary artery calcification; Atherosclerosis; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; TYG INDEX; CALCIUM; ASSOCIATION; IMPACT; ATHEROSCLEROSIS; HYPERGLYCEMIA; EVENTS;

D O I：

10.1186/s12933-020-01008-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Data on the relationship between the triglyceride glucose (TyG) index and coronary artery calcification (CAC) progression is limited. This longitudinal study evaluated the association of TyG index with CAC progression in asymptomatic adults. Methods We enrolled 12,326 asymptomatic Korean adults who had at least two CAC evaluations. The TyG index was determined using ln (fasting triglycerides [mg/dL] x fasting glucose [mg/dL]/2). CAC progression was defined as a difference >= 2.5 between the square roots (root) of the baseline and follow-up coronary artery calcium score (CACS) (Delta root transformed CACS). Annualized Delta root transformed CACS was defined as Delta root transformed CACS divided by the inter-scan period. Results During a mean 3.3 years, the overall incidence of CAC progression was 30.6%. The incidence of CAC progression (group I [lowest]: 22.7% versus [vs.] group II: 31.7% vs. group III [highest]: 37.5%, P < 0.001) and annualized Delta root transformed CACS (group I: 0.46 +/- 1.44 vs. group II: 0.71 +/- 2.02 vs. group III: 0.87 +/- 1.75, P < 0.001) were markedly elevated with increasing TyG index tertiles. Multivariate linear regression analysis showed that TyG index was associated with annualized Delta root transformed CACS (beta = 0.066, P = 0.036). In multivariate logistic regression analysis, the TyG index was significantly associated with CAC progression in baseline CACS <= 100. Conclusion The TyG index is an independent predictor of CAC progression, especially in adults without heavy baseline CAC.

引用

页数：8

共 42 条

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