Enantioselective Hydrogenation of Diarylmethanimines for Synthesis of Chiral Diarylmethylamines

被引：28

作者：

Kong, Duanyang ^{[1
]}

Li, Meina ^{[1
]}

Zi, Guofu ^{[1
]}

Hou, Guohua ^{[1
]}

He, Yong ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Chem, Key Lab Radiopharmaceut, Beijing 100875, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 15期

基金：

中央高校基本科研业务费专项资金资助; 中国国家自然科学基金;

关键词：

CATALYZED ASYMMETRIC HYDROGENATION; N-H IMINES; REDUCTIVE AMINATION; ARYLBORONIC ACIDS; CETIRIZINE DIHYDROCHLORIDE; COOPERATIVE CATALYSIS; PHOSPHORUS LIGANDS; ARYLATION; AMINES; TOSYLARYLIMINES;

D O I：

10.1021/acs.joc.6b01273

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective hydrogenation of N-sub-stituted diarylmethanimines under mild conditions has been first realized by using an iridium catalyst with a chiral f-spiroPhos ligand. This method provides an efficient access to the asymmetric synthesis of a variety of chiral diarylmethylamines and their derivatives with excellent enantioselectivities (up to 99.4% ee) and high turnover numbers (TON up to 4000).

引用

页码：6640 / 6648

页数：9

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