First Friedel-Crafts Reaction of the Baylis-Hillman Adducts Derived from Nitroolefins: Application towards Synthesis of Pyrrolidines and Spiropyrrolidines

被引：22

作者：

Bakthadoss, Manickam ^{[1
]}

Sivakumar, Nagappan ^{[1
]}

机构：

[1] Univ Madras, Dept Organ Chem, Madras 600025, Tamil Nadu, India

来源：

SYNLETT | 2011年 / 09期

关键词：

Baylis-Hillman reaction; Friedel-Crafts reaction; intermolecular [3+2] cycloaddition; arylation; spiro compounds; ONE-POT TRANSFORMATION; C-C BONDS; TANDEM CONSTRUCTION; ACETATES; FACILE; PROTOCOL; DESIGN; ENTRY;

D O I：

10.1055/s-0030-1260557

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and simple protocol for the arylation of Baylis-Hillman adducts derived from nitroolefins leading to novel classes of (E)-2-nitro-1,3-diarylprop-1-enes and 1-[(E)-2-nitro-3-arylallyl]naphthalenes via an intermolecular Friedel-Crafts reaction have been achieved. Further application of these compounds has been demonstrated for the synthesis of pyrrolidines and 3-spiropyrrolidines which are integral components of many natural products and bioactive molecules.

引用

页码：1296 / 1302

页数：7

共 37 条

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