A Novel PIK3CA Hotspot Mutation in Isfahanian Breast Cancer Patients

被引：1

作者：

Gharbi, Sedigheh ^{[1
]}

Faghihi, Mehri ^{[2
]}

Tavassoli, Manoochehr ^{[1
]}

机构：

[1] Univ Isfahan, Dept Biol, Fac Sci, Hezar Jarib, Isfahan, Iran

[2] Med Sci Univ Isfahan, Div Oncol, Esfahan, Iran

来源：

CANCER INVESTIGATION | 2011年 / 29卷 / 04期

关键词：

PIK3CA; PI3K; Breast cancer; Mutation; Akt; MAMMARY EPITHELIAL-CELLS; TRASTUZUMAB RESISTANCE; HIGH-FREQUENCY; PTEN LOSS; GENE; CARCINOMA; CONTRIBUTES; P110-ALPHA; CORRELATE; PATTERNS;

D O I：

10.3109/07357907.2010.550593

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Somatic mutations of phosphatidylinositol 3-kinase (PI3K) catalytic subunit (PIK3CA) play an important role in tumorigenesis. Using PCR-SSCP, followed by sequencing, we examined the PIK3CA gene over the previously identified mutational hotspots in a panel of 50 breast cancer and 5 normal breast tissue, as well as 50 normal blood samples isolated from a population of Iranian patients. In the present study, the frequency of PIK3CA mutation was 14%%. However, the previously identified hotspot mutations in exons 20 were completely absent in these breast cancer samples. Instead, we found a new hotspot mutation (3 of 50 samples) in exon 20.</.

引用

页码：313 / 317

页数：5

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