Diasteroselective and Enantioselective Ir-Catalyzed Allylic Substitutions of 1-Substituted 1-Fluoro-1-(arenesulfonyl)methylene Derivatives

被引：15
作者：
Chen, Jiteng [1 ,2 ]
Zhao, Xiaoming [1 ,2 ]
Dan, Wenyan [1 ,2 ]
机构：
[1] Tongji Univ, Shanghai Key Lab Chem Assessment & Sustainabil, Sch Chem Technol & Engn, 1239 Siping Rd, Shanghai 200092, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 354 Fenglin Rd, Shanghai 200032, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 19期
基金：
美国国家科学基金会;
关键词：
ALLYLATION REACTION; ALKYLATION; ENANTIO; FLUORINATION; DIASTEREO;
D O I：
10.1021/acs.joc.7b01782
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
diasteroselective and enantioselective Ir-catalyzed allylic substitutions of 1-substituted 1-fluoro-1-(arenesulfonyl)methylene derivatives are presented, which afford the fluorinated allyl products with two chirality centers. The steric demand of 1-substituted 1-fluoro-1-(arenesulfonyl)methylene derivatives and allylic substrates has a great influence on the dr values of these reactions. The transformation of the branched allyl product into the fluorinated 3,4-dihydro-2H-pyrrole 1-oxide was discussed, as well.
引用
收藏
页码：10693 / 10698
页数：6
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