Calcitonin Gene-Related Peptide (CGRP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Migraine Pathogenesis

被引：9
|
作者：
Christensen, Casper Emil [1 ]
Ashina, Messoud [1 ]
Amin, Faisal Mohammad [1 ,2 ]
机构：
[1] Rigshosp Glostrup, Danish Headache Ctr, Dept Neurol, DK-2600 Copenhagen, Denmark
[2] Rigshosp, Dept Neurorehabil Traumat Brain Injury, DK-2100 Copenhagen, Denmark
来源：
PHARMACEUTICALS | 2022年 / 15卷 / 10期
关键词：
migraine; neurovascular; headache; meningeal artery; cerebral artery; MRI; MR-angiography; RECEPTOR ANTAGONIST TELCAGEPANT; RANDOMIZED CONTROLLED-TRIAL; MIDDLE MENINGEAL ARTERY; BLOOD-BRAIN-BARRIER; PREVENTIVE TREATMENT; DOUBLE-BLIND; HUMAN MODELS; CEREBRAL-ARTERIES; MESSENGER-RNA; ATTACKS;
D O I：
10.3390/ph15101189
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Migraine is a prevalent and debilitating neurologic disorder. Advancements in understanding the underlying pathophysiological mechanisms are spearheading the effort to introduce disease-specific treatment options. In recent years this effort has largely focused on alteration of endogenous neuropeptide signaling, namely the peptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP). Human studies into the pathophysiological underpinnings of CGRP and PACAP in migraine are manifold and here we review the works investigating these neuropeptides in patients suffering from migraine in order to elucidate the background for developing new treatment options for this vastly disabling disorder.
引用
收藏
页数：11
相关论文
共 50 条
  • [21] Clinical importance of adenylate cyclase-activating polypeptide (PACAP)
    Heinzlmann, Andrea
    Koves, Katalin
    ORVOSI HETILAP, 2023, 164 (33) : 1300 - 1310
  • [22] Calcitonin Gene-Related Peptide (CGRP): A New Target for Migraine
    Russo, Andrew F.
    ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55, 2015, 55 : 533 - 552
  • [23] Pituitary adenylate cyclase-activating polypeptide receptors in the trigeminovascular system: implications for migraine
    Sundrum, Tahlia
    Walker, Christopher S.
    BRITISH JOURNAL OF PHARMACOLOGY, 2018, 175 (21) : 4109 - 4120
  • [24] Calcitonin gene-related peptide and migraine
    Karsan, Nazia
    Goadsby, Peter J.
    CURRENT OPINION IN NEUROLOGY, 2015, 28 (03) : 250 - 254
  • [25] Transport of the pituitary adenylate cyclase-activating polypeptide across the blood-brain barrier: implications for migraine
    Faisal Mohammad Amin
    Henrik Winther Schytz
    The Journal of Headache and Pain, 2018, 19
  • [26] Investigation of the pathophysiological mechanisms of migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38
    Amin, Faisal Mohammad
    Hougaard, Anders
    Schytz, Henrik W.
    Asghar, Mohammad S.
    Lundholm, Elisabet
    Parvaiz, Arushma I.
    de Koning, Patrick J. H.
    Andersen, Malene R.
    Larsson, Henrik B. W.
    Fahrenkrug, Jan
    Olesen, Jes
    Ashina, Messoud
    BRAIN, 2014, 137 : 779 - 794
  • [27] Calcitonin Gene-Related Peptide (CGRP) and Migraine Current Understanding and State of Development
    Bigal, Marcelo E.
    Walter, Sarah
    Rapoport, Alan M.
    HEADACHE, 2013, 53 (08): : 1230 - 1244
  • [28] The Role of Biomarkers Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and Vasoactive Intestinal Peptide (VIP) in Chronic and Episodic Migraines: A Meta-Analysis
    Thapa, Sangharsha
    Shah, Sangam
    Bhattarai, Abhinav
    Yadav, Rukesh
    Yu, Fang
    Chand, Swati
    Li, Jin
    ACTA NEUROLOGICA SCANDINAVICA, 2024, 2024
  • [29] Pituitary adenylate cyclase activating polypeptide (PACAP), stress, and sex hormones
    King, S. Bradley
    Toufexis, Donna J.
    Hammack, Sayamwong E.
    STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, 2017, 20 (05): : 465 - 475
  • [30] Calcitonin gene-related peptide: a key player neuropeptide in migraine
    Ramos-Romero, Marta L.
    Sobrino-Mejia, Fidel E.
    REVISTA DE NEUROLOGIA, 2016, 63 (10) : 460 - 468
12345