Calcitonin Gene-Related Peptide (CGRP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Migraine Pathogenesis

被引：10

作者：

Christensen, Casper Emil ^{[1
]}

Ashina, Messoud ^{[1
]}

Amin, Faisal Mohammad ^{[1
,2
]}

机构：

[1] Rigshosp Glostrup, Danish Headache Ctr, Dept Neurol, DK-2600 Copenhagen, Denmark

[2] Rigshosp, Dept Neurorehabil Traumat Brain Injury, DK-2100 Copenhagen, Denmark

来源：

PHARMACEUTICALS | 2022年 / 15卷 / 10期

关键词：

migraine; neurovascular; headache; meningeal artery; cerebral artery; MRI; MR-angiography; RECEPTOR ANTAGONIST TELCAGEPANT; RANDOMIZED CONTROLLED-TRIAL; MIDDLE MENINGEAL ARTERY; BLOOD-BRAIN-BARRIER; PREVENTIVE TREATMENT; DOUBLE-BLIND; HUMAN MODELS; CEREBRAL-ARTERIES; MESSENGER-RNA; ATTACKS;

D O I：

10.3390/ph15101189

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Migraine is a prevalent and debilitating neurologic disorder. Advancements in understanding the underlying pathophysiological mechanisms are spearheading the effort to introduce disease-specific treatment options. In recent years this effort has largely focused on alteration of endogenous neuropeptide signaling, namely the peptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP). Human studies into the pathophysiological underpinnings of CGRP and PACAP in migraine are manifold and here we review the works investigating these neuropeptides in patients suffering from migraine in order to elucidate the background for developing new treatment options for this vastly disabling disorder.

引用

页数：11

共 82 条

[71] Fremanezumab for the Preventive Treatment of Chronic Migraine [J].

Silberstein, Stephen D. ;

Dodick, David W. ;

Bigal, Marcelo E. ;

Yeung, Paul P. ;

Goadsby, Peter J. ;

Blankenbiller, Tricia ;

Grozinski-Wolff, Melissa ;

Yang, Ronghua ;

Ma, Yuju ;

Aycardi, Ernesto .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (22) :2113-2122

[72] Efficacy and safety of galcanezumab for the prevention of episodic migraine: Results of the EVOLVE-2 Phase 3 randomized controlled clinical trial [J].

Skljarevski, Vladimir ;

Matharu, Manjit ;

Millen, Brian A. ;

Ossipov, Michael H. ;

Kim, Byung-Kun ;

Yang, Jyun Yan .

CEPHALALGIA, 2018, 38 (08) :1442-1454

[73] Evaluation of Galcanezumab for the Prevention of Episodic Migraine The EVOLVE-1 Randomized Clinical Trial [J].

Stauffer, Virginia L. ;

Dodick, David W. ;

Zhang, Qi ;

Carter, Jeffrey N. ;

Ailani, Jessica ;

Conley, Robert R. .

JAMA NEUROLOGY, 2018, 75 (09) :1080-1088

[74] Safety and efficacy of AMG 334 for prevention of episodic migraine: a randomised, double-blind, placebo-controlled, phase 2 trial [J].

Sun, Hong ;

Dodick, David W. ;

Silberstein, Stephen ;

Goadsby, Peter J. ;

Reuter, Uwe ;

Ashina, Messoud ;

Saper, Joel ;

Cady, Roger ;

Chon, Yun ;

Dietrich, Julie ;

Lenz, Robert .

LANCET NEUROLOGY, 2016, 15 (04) :382-390

[75]

Thomsen L L, 1994, Eur J Neurol, V1, P73, DOI 10.1111/j.1468-1331.1994.tb00053.x

[76] Physiotherapy for tension-type headache: a controlled study [J].

Torelli, P ;

Jensen, R ;

Olesen, J .

CEPHALALGIA, 2004, 24 (01) :29-36

[77] No increase of calcitonin gene-related peptide in jugular blood during migraine [J].

Tvedskov, JF ;

Lipka, K ;

Ashina, M ;

Iversen, HK ;

Schifter, S ;

Olesen, J .

ANNALS OF NEUROLOGY, 2005, 58 (04) :561-568

[78]

US Food and Drug Administration, FDA APPR NOV PREV TR

[79] Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery [J].

Vaudry, David ;

Falluel-Morel, Anthony ;

Bourgault, Steve ;

Basille, Magali ;

Burel, Delphine ;

Wurtz, Olivier ;

Fournier, Alain ;

Chow, Billy K. C. ;

Hashimoto, Hitoshi ;

Galas, Ludovic ;

Vaudry, Hubert .

PHARMACOLOGICAL REVIEWS, 2009, 61 (03) :283-357

[80] Effect of the H1-antihistamine clemastine on PACAP38 induced migraine [J].

Vollesen, Luise Haulund ;

Guo, Song ;

Andersen, Malene Rohr ;

Ashina, Messoud .

CEPHALALGIA, 2019, 39 (05) :597-607

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