Calcitonin Gene-Related Peptide (CGRP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Migraine Pathogenesis

被引：10
作者：
Christensen, Casper Emil [1 ]
Ashina, Messoud [1 ]
Amin, Faisal Mohammad [1 ,2 ]
机构：
[1] Rigshosp Glostrup, Danish Headache Ctr, Dept Neurol, DK-2600 Copenhagen, Denmark
[2] Rigshosp, Dept Neurorehabil Traumat Brain Injury, DK-2100 Copenhagen, Denmark
来源：
PHARMACEUTICALS | 2022年 / 15卷 / 10期
关键词：
migraine; neurovascular; headache; meningeal artery; cerebral artery; MRI; MR-angiography; RECEPTOR ANTAGONIST TELCAGEPANT; RANDOMIZED CONTROLLED-TRIAL; MIDDLE MENINGEAL ARTERY; BLOOD-BRAIN-BARRIER; PREVENTIVE TREATMENT; DOUBLE-BLIND; HUMAN MODELS; CEREBRAL-ARTERIES; MESSENGER-RNA; ATTACKS;
D O I：
10.3390/ph15101189
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Migraine is a prevalent and debilitating neurologic disorder. Advancements in understanding the underlying pathophysiological mechanisms are spearheading the effort to introduce disease-specific treatment options. In recent years this effort has largely focused on alteration of endogenous neuropeptide signaling, namely the peptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP). Human studies into the pathophysiological underpinnings of CGRP and PACAP in migraine are manifold and here we review the works investigating these neuropeptides in patients suffering from migraine in order to elucidate the background for developing new treatment options for this vastly disabling disorder.
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页数：11
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