New Insight Into A1 Adenosine Receptors in Diabetes Treatment

被引：8

作者：

Wojcik, Marzena ^{[1
]}

Zieleniak, Andrzej ^{[1
]}

Wozniak, Lucyna A. ^{[1
]}

机构：

[1] Med Univ Lodz, Dept Biol Struct, PL-90752 Lodz, Poland

来源：

CURRENT PHARMACEUTICAL DESIGN | 2010年 / 16卷 / 38期

关键词：

Adenosine receptors; agonists; antagonists; diabetes; insulin resistance; lipolysis; RAT B-LYMPHOCYTES; FREE FATTY-ACIDS; INSULIN-RESISTANCE; PARTIAL AGONIST; MEDICINAL CHEMISTRY; GLUCOSE-TOLERANCE; A(2B) RECEPTORS; ZUCKER RATS; IN-VIVO; PHARMACOLOGY;

D O I：

10.2174/138161210794519066

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The A(1) adenosine receptors (A(1)AR), belonging to the rhodopsin-like superfamily of the G-protein-coupled receptors (GPCRs), may regulate many various cellular processes in cardiovascular, renal, and central nervous systems. In addition, since the A(1)AR possesses antilipolytic properties, numerous A(1)AR agonists and antagonists have been developed, but only some of them with the most promising selective properties in vitro have been advanced to animal studies and clinical trials. In this review, we have summarized the studies on the utility of A(1)AR selective agonists and antagonists in the regulation of lipid and carbohydrate metabolism and their potential therapeutic applications in diabetes.

引用

页码：4237 / 4242

页数：6

共 50 条

[1] Flavonoids as antagonists at A1 adenosine receptors
Alexander, Stephen P. H.
PHYTOTHERAPY RESEARCH, 2006, 20 (11) : 1009 - 1012
[2] Adenosine A1 receptors and vascular reactivity
Wang, Y.
Yang, J. N.
Arner, A.
Boels, P. J. M.
Fredholm, B. B.
ACTA PHYSIOLOGICA, 2010, 199 (02) : 211 - 220
[3] Adenosine receptors and cardiovascular diseaseThe adenosine-1 receptor (A1) and A1 selective ligands
E. S. Hayes
Cardiovascular Toxicology, 2003, 3 (1) : 71 - 88
[4] Adenosine receptors and diabetes: Focus on the A2B adenosine receptor subtype
Merighi, Stefania
Borea, Pier Andrea
Gessi, Stefania
PHARMACOLOGICAL RESEARCH, 2015, 99 : 229 - 236
[5] Therapeutic potential of A1 adenosine receptor ligands:: a survey of recent patent literature
Giorgi, Irene
Nieri, Paola
EXPERT OPINION ON THERAPEUTIC PATENTS, 2008, 18 (07) : 677 - 691
[6] Feeding desensitizes A1 adenosine receptors in adipose through FOXO1-mediated transcriptional regulation
Granade, Mitchell E.
Hargett, Stefan R.
Lank, Daniel S.
Lemke, Michael C.
Luse, Melissa A.
Isakson, Brant E.
Bochkis, Irina M.
Linden, Joel
Harris, Thurl E.
MOLECULAR METABOLISM, 2022, 63
[7] Adenosine A1 receptors do not play a major role in the regulation of lipogenic gene expression in hepatocytes
Yang, Ming
Chu, Ruth
Chisholm, Jeffrey W.
Doege, Holger
Belardinelli, Luiz
Dhalla, Arvinder K.
EUROPEAN JOURNAL OF PHARMACOLOGY, 2012, 683 (1-3) : 332 - 339
[8] Roles of Adenosine A1 and A2A Receptors in the Control of Micturition in Rats
Kitta, Takeya
Chancellor, Michael B.
de Groat, William C.
Kuno, Sadako
Nonomura, Katsuya
Yoshimura, Naoki
NEUROUROLOGY AND URODYNAMICS, 2014, 33 (08) : 1259 - 1265
[9] Therapeutic potentials of agonist and antagonist of adenosine receptors in type 2 diabetes
Sanni, Olakunle
Terre'Blanche, G.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 2021, 22 (04): : 1073 - 1090
[10] A1 Receptors Ligands: Past, Present and Future Trends
Schenone, S.
Brullo, C.
Musumeci, F.
Bruno, O.
Botta, M.
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2010, 10 (09) : 878 - 901

← 1 2 3 4 5 →