Pervasive roles of microRNAs in cardiovascular biology

被引：999

作者：

Small, Eric M. ^{[1
]}

Olson, Eric N. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

来源：

NATURE | 2011年 / 469卷 / 7330期

基金：

美国国家卫生研究院;

关键词：

NEOINTIMAL LESION FORMATION; CONGENITAL HEART-DISEASE; MUSCLE-SPECIFIC MICRORNA; CORONARY-ARTERY-DISEASE; EMBRYONIC STEM-CELLS; CHANNEL GENES HCN2; CARDIAC-HYPERTROPHY; VASCULAR INTEGRITY; FAILURE PATIENTS; DOWN-REGULATION;

D O I：

10.1038/nature09783

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

First recognized as regulators of development in worms and fruitflies, microRNAs are emerging as pivotal modulators of mammalian cardiovascular development and disease. Individual microRNAs modulate the expression of collections of messenger RNA targets that often have related functions, thereby governing complex biological processes. The wide-ranging functions of microRNAs in the cardiovascular system have provided new perspectives on disease mechanisms and have revealed intriguing therapeutic targets, as well as diagnostics, for a variety of cardiovascular disorders.

引用

页码：336 / 342

页数：7

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