Association of VDR ApaI and TaqI Gene Polymorphisms with the Risk of Scleroderma and Behcet's Disease

被引：15

作者：

Kamal, Asmaa ^{[1
]}

Gamal, Sherif M. ^{[2
]}

Elgengehy, Fatema T. ^{[2
]}

Alkemary, Alkhateeb K. ^{[3
]}

Siam, Ibrahem ^{[4
]}

机构：

[1] Cairo Univ, Fac Med, Dept Clin & Chem Pathol, 1 Al Saray St, Cairo 11562, Egypt

[2] Cairo Univ, Dept Rheumatol & Rehabil, Fac Med, Cairo, Egypt

[3] Cairo Univ, Internal Med Dept, Fac Med, Cairo, Egypt

[4] Natl Res Ctr, Internal Med Dept, Cairo, Egypt

来源：

IMMUNOLOGICAL INVESTIGATIONS | 2016年 / 45卷 / 06期

关键词：

Behcet's disease; gene polymorphism; scleroderma; VDR; SYSTEMIC-LUPUS-ERYTHEMATOSUS; D-RECEPTOR POLYMORPHISMS; VITAMIN-D; RHEUMATOID-ARTHRITIS; SUSCEPTIBILITY; METAANALYSIS; SCLEROSIS; VARIANTS; CANCER; FOKI;

D O I：

10.1080/08820139.2016.1180302

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been reported in autoimmune diseases. However, their role in Behcet's disease (BD) and scleroderma remains inconclusive. Our aim was to evaluate vitamin D receptor (ApaI, TaqI) gene polymorphisms in relation to Behcet's disease and scleroderma in Egyptians. The study was conducted on 54 patients with BD, 30 scleroderma patients, and 60 healthy control subjects. VDR (ApaI, TaqI) gene polymorphisms were investigated using polymerase chain reaction-restriction fragment length polymorphism technique. The a allele of ApaI (A/a) polymorphism was significantly associated with increased BD risk (OR = 2.09, 95% CI = 1.18-3.71, p = 0.011), while the TaqI tt genotype was significantly lower in BD patients as compared to control subjects (OR = 0.35, 95% CI = 0.13-0.9, p = 0.026). Carriage of aT VDR haplotype was significantly associated with higher BD risk (OR = 2.28, 95% = 1.14-4.56, p = 0.022). In conclusion, our findings suggest that VDR gene polymorphisms have a significant association with BD in Egyptian patients.

引用

页码：531 / 542

页数：12

共 45 条

[1] Association of vitamin D receptor gene polymorphisms with clinical outcomes of dengue virus infection [J].

Alagarasu, K. ;

Honap, T. ;

Mulay, A. P. ;

Bachal, R. V. ;

Shah, P. S. ;

Cecilia, D. .

HUMAN IMMUNOLOGY, 2012, 73 (11) :1194-1199

[2] Vitamin D-Related Genetic Variants, Interactions with Vitamin D Exposure, and Breast Cancer Risk among Caucasian Women in Ontario [J].

Anderson, Laura N. ;

Cotterchio, Michelle ;

Cole, David E. C. ;

Knight, Julia A. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2011, 20 (08) :1708-1717

[3] PRELIMINARY CRITERIA FOR THE CLASSIFICATION OF SYSTEMIC-SCLEROSIS (SCLERODERMA) [J].

不详 .

ARTHRITIS AND RHEUMATISM, 1980, 23 (05) :581-590

[4] Association between vitamin D receptor (VDR) gene polymorphisms and systemic lupus erythematosus in Portuguese patients [J].

Carvalho, C. ;

Marinho, A. ;

Leal, B. ;

Bettencourt, A. ;

Boleixa, D. ;

Almeida, I. ;

Farinha, F. ;

Costa, P. P. ;

Vasconcelos, C. ;

Silva, B. M. .

LUPUS, 2015, 24 (08) :846-853

[5]

CLEMENTS P, 1995, J RHEUMATOL, V22, P1281

[6] Relationship between vitamin D receptor gene (VDR) polymorphisms, vitamin D status, osteoarthritis and intervertebral disc degeneration [J].

Colombini, Alessandra ;

Cauci, Sabina ;

Lombardi, Giovanni ;

Lanteri, Patrizia ;

Croiset, Samantha ;

Brayda-Bruno, Marco ;

Banfi, Giuseppe .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2013, 138 :24-40

[7] The International Criteria for Behcet's Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria [J].

Davatchi, F. ;

Assaad-Khalil, S. ;

Calamia, K. T. ;

Crook, J. E. ;

Sadeghi-Abdollahi, B. ;

Schirmer, M. ;

Tzellos, T. ;

Zouboulis, C. C. ;

Akhlagi, M. ;

Al-Dalaan, A. ;

Alekberova, Z. S. ;

Ali, A. A. ;

Altenburg, A. ;

Arromdee, E. ;

Baltaci, M. ;

Bastos, M. ;

Benamour, S. ;

Ben Ghorbel, I. ;

Boyvat, A. ;

Carvalho, L. ;

Chen, W. ;

Ben-Chetrit, E. ;

Chams-Davatchi, C. ;

Correia, J. A. ;

Crespo, J. ;

Dias, C. ;

Dong, Y. ;

Paixao-Duarte, F. ;

Elmuntaser, K. ;

Elonakov, A. V. ;

Grana Gil, J. ;

Haghdoost, A-A. ;

Hayani, R. M. ;

Houman, H. ;

Isayeva, A. R. ;

Jamshidi, A. R. ;

Kaklamanis, P. ;

Kumar, A. ;

Kyrgidis, A. ;

Madanat, W. ;

Nadji, A. ;

Namba, K. ;

Ohno, S. ;

Olivieri, I. ;

Vaz Patto, J. ;

Pipitone, N. ;

de Queiroz, M. V. ;

Ramos, F. ;

Resende, C. ;

Rosa, C. M. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2014, 28 (03) :338-347

[8] Role of vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D level in Egyptian female patients with systemic lupus erythematosus [J].

Emerah, Ahmed A. ;

El-Shal, Amal S. .

MOLECULAR BIOLOGY REPORTS, 2013, 40 (11) :6151-6162

[9] Vitamin D and tuberculosis: a review on a hot topic [J].

Facchini, Ludovica ;

Venturini, Elisabetta ;

Galli, Luisa ;

de Martino, Maurizio ;

Chiappini, Elena .

JOURNAL OF CHEMOTHERAPY, 2015, 27 (03) :128-138

[10] Vitamin D receptor gene polymorphisms and hepatocellular carcinoma in alcoholic cirrhosis [J].

Falleti, Edmondo ;

Bitetto, Davide ;

Fabris, Carlo ;

Cussigh, Annarosa ;

Fontanini, Elisabetta ;

Fornasiere, Ezio ;

Fumolo, Elisa ;

Bignulin, Sara ;

Cmet, Sara ;

Minisini, Rosalba ;

Pirisi, Mario ;

Toniutto, Pierluigi .

WORLD JOURNAL OF GASTROENTEROLOGY, 2010, 16 (24) :3016-3024

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