The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn

被引：21
作者：
Fatmawati, Sri [1 ]
Ersama, Taslim [1 ]
Shimizu, Kuniyoshi [2 ]
机构：
[1] Inst Teknol Sepuluh Nopember, Dept Chem, Fac Math & Nat Sci, Surabaya 60111, Indonesia
[2] Kyushu Univ, Fac Agr, Dept Agr & Environm Sci, Fukuoka 8128581, Japan
来源：
PHYTOMEDICINE | 2015年 / 22卷 / 01期
关键词：
Aldose reductase; Mangostin; Garcinia mangostana; Xanthone; Diabetic complications; XANTHONES; APOPTOSIS; ALPHA;
D O I：
10.1016/j.phymed.2014.11.001
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC50 value of 11.98 mu g/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC50 of 3.48 mu M. (C) 2015 Elsevier GmbH. All rights reserved.
引用
收藏
页码：49 / 51
页数：3
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