Mitigation of evolved bacterial resistance to phage therapy

被引：36
作者：
Torres-Barcelo, Clara [1 ]
Turner, Paul E. [2 ,3 ]
Buckling, Angus [4 ]
机构：
[1] INRAE, Plant Pathol, F-84140 Montfavet, France
[2] Yale Univ, Dept Ecol & Evolutionary Biol, New Haven, CT USA
[3] Yale Sch Med, Program Microbiol, New Haven, CT USA
[4] Univ Exeter, Biosci, Penryn TR10 9FE, England
来源：
CURRENT OPINION IN VIROLOGY | 2022年 / 53卷
关键词：
D O I：
10.1016/j.coviro.2022.101201
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The ease with which bacteria can evolve resistance to phages is a key consideration for development of phage therapy. Here, we review recent work on the different evolutionary and ecological approaches to mitigate the problem. The approaches are broadly categorised into two areas: Minimising evolved phage resistance; and Directing phage-resistance evolution towards therapeutically beneficial outcomes.
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页数：5
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