Recent trends in biodegradable polyester nanomaterials for cancer therapy

被引:46
作者
Gupta, Piyush Kumar [1 ]
Gahtori, Rekha [2 ]
Govarthanan, Kavitha [3 ]
Sharma, Vineeta [3 ]
Pappuru, Sreenath [4 ]
Pandit, Soumya [1 ]
Mathuriya, Abhilasha Singh [1 ]
Dholpuria, Sunny [1 ]
Bishi, Dillip Kumar [5 ]
机构
[1] Sharda Univ, Sch Basic Sci & Res, Dept Life Sci, Plot 32 34,Knowledge Pk 3, Greater Noida 201310, Uttar Pradesh, India
[2] Kumaun Univ, Dept Biotechnol, Bhimtal Campus, Naini Tal 263136, Uttarakhand, India
[3] Indian Inst Technol Madras, Bhupat Jyoti Mehta Sch Biosci, Dept Biotechnol, Chennai 600036, Tamil Nadu, India
[4] Technion Israel Inst Technol, Wolfson Fac Chem Engn, IL-3200003 Haifa, Israel
[5] Rama Devi Womens Univ, Dept Biotechnol, Bhubaneswar 751022, Odisha, India
来源
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2021年 / 127卷
关键词
Polyester nanomaterials; Drug delivery; Cancer therapy; Metal-free synthesis; Clinical application; RING-OPENING COPOLYMERIZATION; CORE-SHELL NANOPARTICLES; POLYMERIC NANOPARTICLES; BIOMEDICAL APPLICATIONS; ALTERNATING COPOLYMERIZATION; DRUG-RESISTANCE; BREAST-CANCER; LEWIS PAIRS; MPEG-PLA; DELIVERY;
D O I
10.1016/j.msec.2021.112198
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Biodegradable polyester nanomaterials-based drug delivery vehicles (DDVs) have been largely used in most of the cancer treatments due to its high biological performance and wider applications. In several previous studies, various biodegradable and biocompatible polyester backbones were used which are poly(lactic acid) (PLA), poly (epsilon-caprolactone) (PCL), poly(propylene fumarate) (PPF), poly(lactic-co-glycolic acid) (PLGA), poly(propylene carbonate) (PPC), polyhydroxyalkanoates (PHA), and poly(butylene succinate) (PBS). These polyesters were fabricated into therapeutic nanoparticles that carry drug molecules to the target site during the cancer disease treatment. In this review, we elaborately discussed the chemical synthesis of different synthetic polyesters and their use as nanodrug carriers (NCs) in cancer treatment. Further, we highlighted in brief the recent developments of metal-free semi-aromatic polyester nanomaterials along with its role as cancer drug delivery vehicles.
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页数:13
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