Synthesis and antiviral activity of novel thioether derivatives containing 1,3,4-oxadiazole/thiadiazole and emodin moieties

被引：14

作者：

Dong, Liangrun ^{[1
]}

Song, Baojing ^{[2
]}

Wu, Jian ^{[1
]}

Wu, Zengxue ^{[1
]}

Zhu, Yunying ^{[1
]}

Chen, Xuewen ^{[1
]}

Hu, Deyu ^{[1
]}

机构：

[1] Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Minist Educ, Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Peoples R China

[2] Guizhou Univ, Coll Chem & Chem Engn, Guiyang 550003, Peoples R China

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2016年 / 191卷 / 06期

关键词：

Thioether derivative; 1,3,4-oxadiazole/thiadiazole; emodin; synthesis; antiviral activity; tobacco mosaic virus; TOBACCO-MOSAIC-VIRUS; SULFONE DERIVATIVES; ANTIFUNGAL ACTIVITY; 1,3,4-THIADIAZOLES; 3D-QSAR;

D O I：

10.1080/10426507.2015.1114944

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of novel thioether derivatives containing 1,3,4-oxadiazole/thiadiazole and emodin moieties were designed and synthesized. The structures of the target compounds were confirmed by H-1 NMR, C-13 NMR, Infrared, and elemental analysis. The results of bioactivity analysis showed that most of the target compounds exhibited moderate to good antiviral activity against tobacco mosaic virus at a concentration of 500mg/L. Especially, among the title compounds, Y2, Y8, and Y10 possessed appreciable curative activity in vivo, with inhibition rates of 50.51, 52.08, and 54.62%, respectively, which were similar to that of Ningnanmycin (53.40%).

引用

页码：904 / 907

页数：4

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