Hematopoietic stem cell transplantation for blood cancers in the era of precision medicine and immunotherapy

被引：29

作者：

Bair, Steven M. ^{[1
]}

Brandstadter, Joshua D. ^{[1
]}

Ayers, Emily C. ^{[1
]}

Stadtmauer, Edward A. ^{[1
]}

机构：

[1] Univ Penn, Perelman Ctr Adv Med, Div Hematol Oncol, 12th Fl,South Pavilion,3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA

来源：

CANCER | 2020年 / 126卷 / 09期

关键词：

allogeneic; autologous; immunotherapy; targeted; transplantation; ACUTE MYELOID-LEUKEMIA; HIGH-DOSE THERAPY; ACUTE LYMPHOBLASTIC-LEUKEMIA; BONE-MARROW-TRANSPLANTATION; MINIMAL RESIDUAL DISEASE; SINGLE-AGENT LENALIDOMIDE; PROSPECTIVE RANDOMIZED-TRIAL; TYROSINE KINASE INHIBITORS; DIAGNOSED MULTIPLE-MYELOMA; ACUTE LYMPHOCYTIC-LEUKEMIA;

D O I：

10.1002/cncr.32659

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hematopoietic stem cell transplantation (HCT) has been an integral component in the treatment of many hematologic malignancies. Since the development of HCT nearly 50 years ago, the role of this modality has evolved as newer treatment approaches have been developed and integrated into the standard of care. In the last decade, novel and highly active targeted therapies and immunotherapies have been approved for many hematologic malignancies, raising the question of whether HCT continues to retain its prominent role in the treatment paradigms of various hematologic malignancies. In this review, the authors have described the current role of autologous and allogeneic HCT in the treatment of patients with acute leukemias, aggressive B-cell lymphomas, and multiple myeloma and discussed how novel targeted therapies and immunotherapies have changed the potential need, timing, and goal of HCT in patients with these diseases.

引用

页码：1837 / 1855

页数：19

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