Genetic studies in Parkinson's disease with an α-synuclein/NACP gene polymorphism in Japan

被引：58
作者：
Izumi, Y
Morino, H
Oda, M
Maruyama, H
Udaka, F
Kameyama, M
Nakamura, S
Kawakami, H
机构：
[1] Hiroshima Univ, Sch Med, Dept Internal Med 3, Minami Ku, Hiroshima 7348551, Japan
[2] Sumitomo Hosp, Dept Neurol, Osaka 5300005, Japan
来源：
NEUROSCIENCE LETTERS | 2001年 / 300卷 / 02期
关键词：
alpha synuclein/NACP promoter polymorphism; risk factor; Parkinson's disease; Japanese population;
D O I：
10.1016/S0304-3940(01)01557-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Dinucleotide repeat polymorphism has been observed in the promoter of the alpha -synuclein (alpha -SYN)/NAC precursor protein (NACP) gene. alpha -SYN/NACP allele 3 (described by Xia et al. (Ann. Neurol., 40 (1996) 207), equivalent to allele 1 described by Krijger et a I. (Ann. Neurol. 45 (1999) 611) is reported to be significantly more frequent among patients with sporadic Parkinson's disease (sPD) than controls. In this study, we genotyped the same alpha -SYN/NACP polymorphism in Japanese sPD patients and healthy controls, but found that any allele showed no significant difference between the two groups. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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收藏
页码：125 / 127
页数：3
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