New triterpenoid saponins from the roots of Platycodon grandiflorum

被引：45

作者：

He, ZD

Qiao, CF

Han, QB

Wang, Y

Ye, WC

Xu, HX ^{[1
]}

机构：

[1] Hong Kong Jockey Club Inst Chinese Med, Chinese Med Lab, Shatin, Hong Kong, Peoples R China

[2] China Pharmaceut Univ, Dept Phytochem, Nanjing 210009, Peoples R China

来源：

TETRAHEDRON | 2005年 / 61卷 / 08期

关键词：

platycosides G1-G3; triterpenoid saponin; Platycodon grandiflorum; Campanulaceae; antiviral activity;

D O I：

10.1016/j.tet.2004.12.032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioassay-directed fractionation of the antiviral active fraction of the roots of Platycodon grandiflorum leads to the isolation of three new triterpenoid saponins, platycosides G1-G3 (1-3), as well as two known saponins, platycodin D3 (4), and platycoside E (5). The structures of the new compounds were elucidated on the basis of their spectral data and chemical evidences. The isolated saponins were tested for their antiviral activities against respiratory syncytial virus (RSV), herpes simplex type 1 virus (HSV-1) and influenza type A virus (Flu A). Compound 4 showed weak anti-RSV activity. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2211 / 2215

页数：5

共 16 条

[1] SAPONINS FROM ROOTS OF PLATYCODON-GRANDIFLORUM .2. ISOLATION AND STRUCTURE OF NEW TRITERPENE GLYCOSIDES [J].