Supreme enLIGHTenment: Damage recognition and signaling in the mammalian UV response

Like their prokaryotic counterparts, mammalian cells can sense light, especially in the ultraviolet (UV) range of the spectrum. After UV exposure, cells mount an elaborate response-called the UV response-that mimics physiological signaling responses except that it targets multiple pathways, thereby lacking the defined specificity of receptor-triggered signal transduction. Despite many years of research, it is still not fully clear how UV radiation is sensed and converted into the "language of cells"-signal reception and transduction. This review focuses on how photonic energy and its primary cellular products are sensed to elicit the UV response.