Susceptibility of Vertilmicin to Modifications by Three Types of Recombinant Aminoglycoside-Modifying Enzymes

被引：4

作者：

Yuan, Min ^{[1
,2
]}

Han, Hui ^{[1
,2
]}

Li, Cong-Ran ^{[1
,2
]}

Yang, Xin-Yi ^{[1
,2
]}

Li, Guo-Qing ^{[1
,2
]}

Cen, Shan ^{[1
,2
]}

Kang, Xi-Xiong ^{[3
]}

Si, Shu-Yi ^{[1
,2
]}

Jiang, Jian-Dong ^{[1
,2
]}

You, Xue-Fu ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Capital Med Univ, Beijing Tiantan Hosp, Clin Lab, Beijing 100050, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 08期

基金：

中国国家自然科学基金;

关键词：

BETA-LACTAMASE; PSEUDOMONAS-AERUGINOSA; NUCLEOTIDE-SEQUENCE; ACETYLTRANSFERASE; GENE; MECHANISM; VARIANT; STRAIN;

D O I：

10.1128/AAC.00300-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The susceptibilities of vertilmicin and seven reference aminoglycosides to modifications by six recombinant aminoglycoside-modifying enzymes, AAC(6')-Ie, APH(2")-Ia, AAC(6')-Ie-APH(2")-Ia, ANT(2")-Ia, AAC(6')-Ib, and AAC(6')-Ib-cr, were studied by coupled spectrophotometric assays in microtiter plates. In comparison to other aminoglycosides, the susceptibility of vertilmicin was 45.8- to 250.0-fold lower for AAC(6')-Ie acetylation, 39.2- to 116.7-fold lower for AAC(6')-Ie-APH(2")-Ia acetylation, and 1.8- to 7.5-fold lower for ANT(2")-Ia adenylation (except that shown by amikacin) while relatively comparable for AAC(6')-Ib acetylation, AAC(6')-Ib-cr acetylation, APH(2")-Ia phosphorylation, and AAC(6')-Ie-APH(2")-Ia phosphorylation.

引用

页码：3950 / 3953

页数：4

共 6 条

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