Fungicidal effect of resveratrol on human infectious fungi

被引：89
作者：
Jung, HJ
Hwang, IA
Sung, WS
Kang, H
Kang, BS
Seu, YB
Lee, DG
机构：
[1] Kyungpook Natl Univ, Dept Microbiol, Coll Nat Sci, Taegu 702701, South Korea
[2] Kyungpook Natl Univ, Dept Microbiol, Sch Life Sci, Taegu 702701, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2005年 / 28卷 / 05期
关键词：
resveratrol; trans-3,5,4 '-trihydroxystilbene; phenolic antioxidant; fungicidal activity; hemolytic effect;
D O I：
10.1007/BF02977758
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Resveratrol, a phenolic antioxidant found in grapes, has been known to mediate various biological activities on the human body. In the present study, we tested the antifungal activity of resveratrol against human pathogenic fungi before carrying out further studies to elucidate the antifungal mechanism(s) of resveratrol. Resveratrol displayed potent antifungal activity against human pathogenic fungi at concentration levels of 10-20 mu g/ml. Furthermore, time-kill curve exhibited fungicidal effect of resveratrol on C. albicans, but the compound had no hemolytic activity against human erythrocytes. The destruction of C. albicans cells by resveratrol was confirmed by scanning electron microscopy. These results suggest that resveratrol could be employed as a therapeutic agent to treat fungal infections of humans.
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收藏
页码：557 / 560
页数：4
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