The function of miRNAs in hepatocarcinogenesis induced by hepatitis B virus X protein

被引：19

作者：

Wang, Ziyao ^{[1
]}

Wu, Zhongjun ^{[1
]}

Huang, Ping ^{[1
]}

机构：

[1] Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Natl Key Clin Dept, Youyi Rd 1, Chongqing 400000, Peoples R China

来源：

ONCOLOGY REPORTS | 2017年 / 38卷 / 02期

关键词：

MicroRNA; HBx; hepatocarcinogenesis; interaction; mechanism; HEPATOCELLULAR-CARCINOMA CELLS; ABNORMAL LIPID-METABOLISM; ABERRANT DNA METHYLATION; NF-KAPPA-B; DOWN-REGULATION; UP-REGULATION; LIVER-CANCER; HEPATOMA-CELLS; PROMOTES PROLIFERATION; EPIGENETIC REPRESSION;

D O I：

10.3892/or.2017.5716

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs are short RNAs that play a crucial role in all biological processes through post-transcriptional regulation for protein-coding genes and inducing mRNA degradation. Hepatitis B virus infection has been considered as a major risk factor in hepatocellular carcinoma, further research indicates that hepatitis B virus X protein (HBx) is one of the critical links of hepatocarcinogenesis. HBx takes part in hepatocarcinogenesis via regulating transcription, signal transduction, apoptosis, protein degradation and DNA repair. miRNA is the important target gene of HBx, their interaction impacts many tumor processes, such as proliferation, apoptosis, invasion, metastasis, differentiation and adipogenesis. In the present study we reviewed the current state of knowledge of regulation pathway of HBx acting on miRNAs, and focused on the role of their interplay in hepatocarcinogenesis.

引用

页码：652 / 664

页数：13

共 50 条

[31] Hepatitis B virus-induced hepatocarcinogenesis: A virological and oncological perspective [J].

Arslan, Ferhat ;

Franci, Gianluigi ;

Nastri, Bianca Maria ;

Pagliano, Pasquale .

JOURNAL OF VIRAL HEPATITIS, 2021, 28 (08) :1104-1109

[32] Interleukin-32 expression induced by hepatitis B virus protein X is mediated through activation of NF-κB [J].

Pan, Xingfei ;

Cao, Hong ;

Lu, Jianxi ;

Shu, Xin ;

Xiong, Xiaojia ;

Hong, Xiaolv ;

Xu, Qihuan ;

Zhu, Huifen ;

Li, Gang ;

Shen, Guanxin .

MOLECULAR IMMUNOLOGY, 2011, 48 (12-13) :1573-1577

[33] SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis [J].

Srisuttee, Ratakorn ;

Koh, Sang Seok ;

Malilas, Waraporn ;

Moon, Jeong ;

Cho, Il-Rae ;

Jhun, Byung Hak ;

Horio, Yoshiyuki ;

Chung, Young-Hwa .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 429 (1-2) :45-50

[34] C-terminal-truncated hepatitis B virus X protein promotes hepatocarcinogenesis by activating the MAPK pathway [J].

Zhang, Chaojun ;

Xiao, Chanchan ;

Ren, Guanhua ;

Cai, Dongmei ;

Long, Long ;

Li, Jilin ;

Li, Kezhi ;

Tang, Yanping ;

Huang, Tianren ;

Deng, Wei .

MICROBIAL PATHOGENESIS, 2021, 159

[35] Epigenetic repression of miR-132 expression by the hepatitis B virus x protein in hepatitis B virus-related hepatocellular carcinoma [J].

Wei, Xufu ;

Tan, Cui ;

Tang, Chengyong ;

Ren, Guosheng ;

Xiang, Tingxiu ;

Qiu, Zhu ;

Liu, Rui ;

Wu, Zhongjun .

CELLULAR SIGNALLING, 2013, 25 (05) :1037-1043

[36] Proteomic Profiling Identifies Aberrant Epigenetic Modifications Induced by Hepatitis B Virus X Protein [J].

Tong, Aiping ;

Gou, Lantu ;

Lau, Quek Choon ;

Chen, Bin ;

Zhao, Xia ;

Li, Jiong ;

Tang, Hong ;

Chen, Lijuan ;

Tang, Minghai ;

Huang, Canhua ;

Wei, Yu-quan .

JOURNAL OF PROTEOME RESEARCH, 2009, 8 (02) :1037-1046

[37] Modulation of Apoptotic Signaling by the Hepatitis B Virus X Protein [J].

Rawat, Siddhartha ;

Clippinger, Amy J. ;

Bouchard, Michael J. .

VIRUSES-BASEL, 2012, 4 (11) :2945-2972

[38] Epigenetic control of metastasis-associated protein 1 gene expression by hepatitis B virus X protein during hepatocarcinogenesis [J].

Lee, M-H ;

Na, H. ;

Na, T-Y ;

Shin, Y-K ;

Seong, J-K ;

Lee, M-O .

ONCOGENESIS, 2012, 1 :e25-e25

[39] Hepatitis B virus HBx gene and hepatocarcinogenesis [J].

Koike, K .

INTERVIROLOGY, 1995, 38 (3-4) :134-142

[40] Epigenetic control of metastasis-associated protein 1 gene expression by hepatitis B virus X protein during hepatocarcinogenesis [J].

M-H Lee ;

H Na ;

T-Y Na ;

Y-K Shin ;

J-K Seong ;

M-O Lee .

Oncogenesis, 2012, 1 :e25-e25

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