Neuromedin U promotes human type 2 immune responses

被引：14
作者：
Ye, Yuan [1 ,2 ]
Luo, Jian [1 ,2 ]
Zeng, Ni [1 ,2 ]
Jiang, Shan [1 ,2 ]
Chen, Wentao [1 ,2 ]
Hoyle, Ryan D. [1 ,2 ]
Klenerman, Paul [3 ,4 ]
Pavord, Ian D. [1 ,2 ]
Xue, Luzheng [1 ,2 ]
机构：
[1] Univ Oxford, Resp Med Unit, Oxford, England
[2] Univ Oxford, NIHR Oxford Biomed Res Ctr, Oxford, England
[3] Univ Oxford, Translat Gastroenterol Unit, Oxford, England
[4] Univ Oxford, Peter Medawar Bldg Pathogen Res, Oxford, England
来源：
MUCOSAL IMMUNOLOGY | 2022年 / 15卷 / 05期
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
INNATE LYMPHOID-CELLS; PROSTAGLANDIN D-2; TH2; CELLS; NEUROPEPTIDE; EXPRESSION; CRTH2; IDENTIFICATION; RECEPTORS; EXACERBATIONS; INFLAMMATION;
D O I：
10.1038/s41385-022-00543-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Type 2 immunity mediates the immune responses against parasites and allergic stimuli. Evidence from studies of cell lines and animals implies that neuromedin U (NmU) acts as a pro-inflammatory mediator of type 2 inflammation. However, the role of NmU in human type 2 immunity remains unclear. Here we investigated the expression of NmU in human blood and airways, and the expression of NmU receptors by human immune cells in blood and lung tissue. We detected human NmU (hNmU-25) in blood and airways with higher concentrations in the latter. NmU receptor 1 (NmUR1) was expressed by most human immune cells with higher levels in type 2 cells including type 2 T helpers, type 2 cytotoxic T cells, group-2 innate lymphoid cells and eosinophils, and was upregulated in lung-resident and activated type 2 cells. We also assessed the effects of NmU in these cells. hNmU-25 elicited type 2 cytokine production by type 2 lymphocytes and induced cell migration, including eosinophils. hNmU-25 also enhanced the type 2 immune response to other stimuli, particularly prostaglandin D-2. These results indicate that NmU could contribute to the pathogenic processes of type 2 immunity-mediated diseases in humans via its pro-inflammatory effects on type 2 lymphocytes and eosinophils.
引用
收藏
页码：990 / 999
页数：10
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