High Carbohydrate Antigen 19-9 Levels Indicate Poor Prognosis of Upper Tract Urothelial Carcinoma

被引：0
|
作者：
Jeong, Seung-hwan [1 ]
Han, Jang Hee [1 ]
Jeong, Chang Wook [1 ,2 ]
Kim, Hyeon Hoe [1 ,2 ]
Kwak, Cheol [1 ,2 ]
Yuk, Hyeong Dong [1 ,2 ]
Ku, Ja Hyeon [1 ,2 ]
机构：
[1] Seoul Natl Univ Hosp, Dept Urol, Seoul, South Korea
[2] Seoul Natl Univ, Dept Urol, Coll Med, Seoul, South Korea
来源：
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
基金：
新加坡国家研究基金会;
关键词：
CA; 19-9; UTUC; prognosis; survival; metastasis; ONCOLOGIC OUTCOMES; SERUM CA-19-9; CA19-9; MARKER; CEA;
D O I：
10.3389/fonc.2022.858813
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Upper tract urothelial carcinoma (UTUC) occurs in urothelial cells from the kidney and the ureters. Carbohydrate antigen 19-9 (CA 19-9) is a tumor marker for pancreatic and gastrointestinal cancers, and its high levels are associated with poor prognosis in bladder cancer. In this study, prospective patients enrolled in the registry of Seoul National University were retrospectively examined to determine the clinical significance of CA 19-9 in UTUC. In 227 patients, high serum CA 19-9 levels reflected a high tumor burden represented by high T and N stages, leading to adverse prognosis in metastasis-free or overall survival. Subsequently, propensity score matching analysis showed that the CA 19-9 level is an independent prognostic factor of UTUC.
引用
收藏
页数：6
相关论文
共 50 条
  • [31] Prognostic role of carcinoembryonic antigen and carbohydrate antigen 19-9 in metastatic colorectal cancer: a BRAF-mutant subset with high CA 19-9 level and poor outcome
    Thomsen, Maria
    Skovlund, Eva
    Sorbye, Halfdan
    Bolstad, Nils
    Nustad, Kjell Johannes
    Glimelius, Bengt
    Pfeiffer, Per
    Kure, Elin H.
    Johansen, Julia S.
    Tveit, Kjell Magne
    Christoffersen, Thoralf
    Guren, Tormod Kyrre
    BRITISH JOURNAL OF CANCER, 2018, 118 (12) : 1609 - 1616
  • [32] Low Expression of GRIM-19 Correlates with Poor Prognosis in Patients with Upper Urinary Tract Urothelial Carcinoma
    Tian, Feng
    Lv, Long
    Liu, Zonglin
    Guan, Sheng
    Jiang, Fengze
    Wang, Qi
    Kalvakolanu, Dhan, V
    Jiang, Sixiong
    Sun, Weibing
    CURRENT CANCER DRUG TARGETS, 2025, 25 (04) : 401 - 411
  • [33] The Levels of Carbohydrate Antigen 19-9 are Associated with Gender and Age in Chinese Population
    Wang, Yan-Zhong
    Zhou, Yan-Wen
    Xie, Xin-You
    Li, Gui-Ling
    Wang, Xiu-Hong
    Li, Feng-Ying
    Le, Zhi-An
    Zhong, Yu-Hong
    Zhang, Jun
    CLINICAL LABORATORY, 2013, 59 (7-8) : 813 - 817
  • [34] Serum carbohydrate antigen 19-9 levels in patients with unilateral hydronephrosis due to urinary lithiasis
    Kutlu, O.
    Celik, O.
    Koksal, I. T.
    Yigit, S.
    Danisman, A.
    MINERVA UROLOGICA E NEFROLOGICA, 2012, 64 (03) : 217 - 221
  • [35] Carbohydrate Antigen 19-9 Levels Associated with Pathological Responses to Preoperative Chemoradiotherapy in Rectal Cancer
    Yeo, Seung-Gu
    Kim, Dae Yong
    Kim, Tae Hyun
    Kim, Sun Young
    Baek, Ji Yeon
    Chang, Hee Jin
    Park, Ji Won
    Oh, Jae Hwan
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2014, 15 (13) : 5383 - 5387
  • [36] Prognostic impact of carcinoembryonic antigen and carbohydrate antigen 19-9 in stage IV colorectal cancer patients after R0 resection
    Abe, Shinya
    Kawai, Kazushige
    Ishihara, Soichiro
    Nozawa, Hiroaki
    Hata, Keisuke
    Kiyomatsu, Tomomichi
    Tanaka, Toshiaki
    Watanabe, Toshiaki
    JOURNAL OF SURGICAL RESEARCH, 2016, 205 (02) : 384 - 392
  • [37] Rheumatoid factor interference in the determination of carbohydrate antigen 19-9 (CA 19-9)
    Berth, Mario
    Bosmans, Eugene
    Everaert, Jacques
    Dierick, Jan
    Schiettecatte, Johan
    Anckaert, Ellen
    Delanghe, Joris
    CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2006, 44 (09) : 1137 - 1139
  • [38] Carbohydrate antigen 19-9 for differential diagnosis of pancreatic carcinoma and chronic pancreatitis
    Su, Si-Biao
    Qin, Shan-Yu
    Chen, Wen
    Luo, Wei
    Jiang, Hai-Xing
    WORLD JOURNAL OF GASTROENTEROLOGY, 2015, 21 (14) : 4323 - 4333
  • [39] Role of Tumour Markers Carbohydrate Antigen 19-9, Carcinoembryonic Antigen, & Alpha Fetoprotein in Carcinoma Gall Bladder
    Rai, Saurabh
    Shekhar, Chandra
    Musa, Osman
    Ansari, Nisar
    Agrawal, Rahul
    Agrawal, Rajat
    Bhore, Almol
    Alam, Shams
    JOURNAL OF EVOLUTION OF MEDICAL AND DENTAL SCIENCES-JEMDS, 2021, 10 (10): : 719 - 723
  • [40] Very High Serum CA 19-9 Levels: A Contraindication to Pancreaticoduodenectomy?
    Turrini, O.
    Schmidt, C. M.
    Moreno, J.
    Parikh, P.
    Matos, J. M.
    House, M. G.
    Zyromski, N. J.
    Nakeeb, A.
    Pitt, H. A.
    Lillemoe, K. D.
    JOURNAL OF GASTROINTESTINAL SURGERY, 2009, 13 (10) : 1791 - 1797
12345