Postmortem redistribution of THC in the pig

被引：47
作者：
Brunet, Bertrand [1 ,2 ]
Hauet, Thierry [2 ,3 ]
Hebrard, William [4 ]
Papet, Yves [1 ]
Mauco, Gerard [2 ,3 ]
Mura, Patrick [1 ]
机构：
[1] Ctr Hosp & Univ Poitiers, Lab Toxicol & Pharmacocinet, F-86021 Poitiers, France
[2] Univ Poitiers, CHU Poitiers, Fac Med & Pharm, INSERM U927, F-86021 Poitiers, France
[3] Ctr Hosp & Univ Poitiers, Biochim Lab, F-86021 Poitiers, France
[4] Inst Natl Rech Agronom, Chirurg Expt Lab, F-17700 Domaine Du Magneraud, Surgeres, France
来源：
INTERNATIONAL JOURNAL OF LEGAL MEDICINE | 2010年 / 124卷 / 06期
关键词：
THC; Cannabinoids; Postmortem redistribution; Animal model; Large White pig; DRUG REDISTRIBUTION; ANIMAL-MODEL; BASIC DRUGS; BLOOD; DELTA-9-TETRAHYDROCANNABINOL; AMITRIPTYLINE; METABOLISM; TISSUES; DELTA-1-TETRAHYDROCANNABINOL; PHARMACOKINETICS;
D O I：
10.1007/s00414-009-0403-2
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
To improve the knowledge of the postmortem redistribution of Delta(9)-tetrahydrocannabinol (THC), an animal model using the Large White pig has been developed, whereby 15 pigs received an intravenous injection of THC (200 A mu g/kg body weight) and were euthanized 2 h after administration. An autopsy was performed on three pigs immediately after being euthanized while the others were stored in supine position at ambient temperature for 6, 15, 24, or 48 h. THC concentration in blood from the vena cava decreased after death whereas left or right cardiac blood concentrations increased. No blood specimens collected from different sites of the carcasses adequately reflected the perimortem THC concentrations. The highest concentrations of THC at anytime were observed in lung tissue, and brain tissue seemed to present the most stable concentrations over time. This study can assist toxicologists in determining which specimens can, most appropriately, be used for interpretation of cannabinoid concentrations in postmortem specimens.
引用
收藏
页码：543 / 549
页数：7
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