Melatonin effect on rat body weight regulation in response to high-fat diet at middle age

被引:69
作者
Puchalski, SS
Green, JN
Rasmussen, DD
机构
[1] VA Puget Sound Hlth Care Syst, Mental Illness Res, Educ & Clin Ctr, Seattle, WA 98108 USA
[2] Univ Washington, Dept Psychiat, Seattle, WA 98195 USA
关键词
melatonin; high-fat diet; body weight; leptin; insulin; visceral fat;
D O I
10.1385/ENDO:21:2:163
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We previously demonstrated that daily melatonin administration to middle-aged rats to restore youthful plasma melatonin levels also decreased body weight, visceral fat, plasma leptin, and plasma insulin to more youthful levels, without detectable changes in consumption of chow diet. We now evaluate: (a) whether melatonin alters consumption of a more precisely quantifiable liquid diet similar in high-fat content to the typical American diet; (b) differences between melatonin-induced endocrine responses in the fasted vs fed state; and (c) time course of these responses. Ten-month-old male Sprague-Dawley rats received liquid diet containing either 0.2 mug/mL melatonin (MELATONIN) or vehicle (CONTROL) (n = 14/treatment); the diet was available throughout each night, but was removed for the final 10 h of each daytime. MELATONIN rats gained 4% body weight during the first 2 wk and then stabilized, whereas CONTROL rats continued to gain for an additional week, achieving 8% gain (p < 0.05 vs MELATONIN). During the first 3 wk, afternoon tail-blood leptin, but not insulin, levels decreased in melatonin-treated rats (p < 0.05 vs CONTROL). After 8 wk, half of the rats were killed at the midpoint of the dark period (NIGHT; fed) and half at the end of the light period (DAYTIME; fasted). NIGHT but not DAYTIME plasma leptin levels were decreased in MELATONIN rats, whereas DAYTIME but not NIGHT plasma insulin levels were decreased (p < 0.05 vs CONTROL). Melatonin treatment did not alter cumulative food consumption. Thus, melatonin decreased weight gain in response to high-fat diet, decreased plasma leptin levels within 3 wk-before decreasing plasma insulin-and exerted these metabolic effects independent of total food consumption.
引用
收藏
页码:163 / 167
页数:5
相关论文
共 24 条
[1]   Plasma insulin concentration is more tightly linked to plasma leptin concentration than is the body mass index [J].
Abbasi, F ;
Carantoni, M ;
McLaughlin, T ;
Reaven, GM .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2000, 49 (04) :544-547
[2]   Regulation of plasma leptin in mice: Influence of age, high-fat diet, and fasting [J].
Ahren, B ;
Mansson, S ;
Gingerich, RL ;
Havel, PJ .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1997, 273 (01) :R113-R120
[3]   Leptin selectively decreases visceral adiposity and enhances insulin action [J].
Barzilai, N ;
Wang, JL ;
Massilon, D ;
Vuguin, P ;
Hawkins, M ;
Rossetti, L .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (12) :3105-3110
[4]   Surgical removal of visceral fat reverses hepatic insulin resistance [J].
Barzilai, N ;
She, L ;
Liu, BQ ;
Vuguin, P ;
Cohen, P ;
Wang, JL ;
Rossetti, L .
DIABETES, 1999, 48 (01) :94-98
[5]   Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight [J].
Baskin, DG ;
Lattemann, DF ;
Seeley, RJ ;
Woods, SC ;
Porte, D ;
Schwartz, MW .
BRAIN RESEARCH, 1999, 848 (1-2) :114-123
[6]   Central role of the adipocyte in the metabolic syndrome [J].
Bergman, RN ;
Van Citters, GW ;
Mittelman, SD ;
Dea, MK ;
Hamilton-Wessler, M ;
Kim, SP ;
Ellmerer, M .
JOURNAL OF INVESTIGATIVE MEDICINE, 2001, 49 (01) :119-126
[7]  
BJORNTORP P, 1995, J INTERN MED, V238, P401
[8]   Melatonin in relation to physiology in adult humans [J].
Cagnacci, A .
JOURNAL OF PINEAL RESEARCH, 1996, 21 (04) :200-213
[9]   Modulation of insulin activities by leptin [J].
Cohen, B ;
Novick, D ;
Rubinstein, M .
SCIENCE, 1996, 274 (5290) :1185-1188
[10]   Short term response of circulating leptin to feeding and fasting in man:: influence of circadian cycle [J].
Dallongeville, J ;
Hecquet, B ;
Lebel, P ;
Edmé, JL ;
Le Fur, C ;
Fruchart, JC ;
Auwerx, J ;
Romon, M .
INTERNATIONAL JOURNAL OF OBESITY, 1998, 22 (08) :728-733