Nanoparticles as contrast agents for photoacoustic brain imaging

被引:46
作者
Liu, Xingang [1 ]
Duan, Yukun [1 ]
Liu, Bin [1 ,2 ,3 ]
机构
[1] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore, Singapore
[2] Joint Sch Natl Univ Singapore, Singapore, Singapore
[3] Tianjin Univ, Int Campus Tianjin Univ, Fuzhou 350207, Peoples R China
来源
AGGREGATE | 2021年 / 2卷 / 01期
关键词
brain imaging; contrast agent; nanoparticle; photoacoustic imaging; MOUSE-BRAIN; PHOTOTHERMAL THERAPY; TOMOGRAPHY; DRUG; ULTRASOUND; TUMORS; BARRIER; SKIN;
D O I
10.1002/agt2.26
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Photoacoustic (PA) imaging has emerged as a promising technique for real-time detection and diagnosis of brain-related pathologies, due to its advantages in deep penetration of ultrasound imaging and high resolution of optical fluorescence imaging. We herein provide an overview on the latest developments of nanoparticles as contrast agents specifically designed for PA imaging of brain tumor, and brain vascular and other brain-related diseases. Five design considerations of high-performance PA contrast agents for brain-related disease diagnosis are discussed, which include (1) strong absorption in NIR or NIR-II window, (2) good biocompatibility, (3) high photothermal conversion efficiency, (4) precise nanostructure control, and (5) specific targeting capability. Challenges and perspectives of developing more robust and universal contrast agents for enhanced PA imaging are discussed at the end.
引用
收藏
页码:4 / 19
页数:16
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