Recent developments of C-4 substituted coumarin derivatives as anticancer agents

被引：184

作者：

Dandriyal, Jyoti ^{[1
]}

Singla, Ramit ^{[1
]}

Kumar, Manvendra ^{[1
]}

Jaitak, Vikas ^{[1
]}

机构：

[1] Cent Univ Punjab, Sch Basic & Appl Sci, Ctr Pharmaceut Sci & Nat Prod, Bathinda 151001, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2016年 / 119卷

关键词：

C-4 substituted coumarin; Anticancer; Synthesis; Mechanism of action; SAR; SOLVENT-FREE CONDITIONS; SOLID ACID CATALYST; PECHMANN CONDENSATION REACTION; SITE-DIRECTED INHIBITION; ANTI-BREAST CANCER; BIOLOGICAL EVALUATION; MICROWAVE IRRADIATION; CHROMENE DERIVATIVES; RECYCLABLE CATALYST; MOLECULAR DOCKING;

D O I：

10.1016/j.ejmech.2016.03.087

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cancer is a prominent cause of death in global. Currently, the numbers of drugs that are in clinical practice are having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand a suitable anticancer drug that has no MDR and side effect. Coumarin scaffold became an attractive subject due to their broad spectrum of pharmacological activities. Coumarin derivatives extensively explored for anticancer activities as it possesses minimum side effect along with multi-drug reversal activity. Coumarin derivatives can act by various mechanisms on different tumor cell lines depending on substitution pattern of the core structure of coumarin. Substitution on coumarin nucleus leads to the search for more potent compounds. In this review, we have made an effort to give a synthetic strategy for the preparation of C-4 substituted coumarin derivatives as anticancer agents based on their mechanism of action and also discuss the SAR of the most active compound. (C) 2016 Elsevier Masson SAS. All rights reserved.

引用

页码：141 / 168

页数：28

共 100 条

[31] Coumarins as novel 17β-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer [J].