Improved cell activity on biodegradable photopolymer scaffolds using titanate nanotube coatings

被引：16

作者：

Beke, S. ^{[1
]}

Barenghi, R. ^{[2
]}

Farkas, B. ^{[1
]}

Romano, I. ^{[1
]}

Koroesi, L. ^{[3
]}

Scaglione, S. ^{[2
]}

Brandi, F. ^{[1
,4
]}

机构：

[1] Ist Italiano Tecnol, I-16163 Genoa, Italy

[2] CNR, IEIIT, I-16149 Genoa, Italy

[3] Enviroinvest Corp, Nanophage Therapy Ctr, Dept Biotechnol, H-7632 Pecs, Hungary

[4] CNR, Ist Nazl Ott, I-56124 Pisa, Italy

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2014年 / 44卷

关键词：

Laser photocuring; Scaffolds; Titanate nanotubes; Tissue engineering; Cell culturing; Excimer laser; MESENCHYMAL STEM-CELLS; TIO2; NANOTUBES; SURFACES; ADHESION; BEHAVIOR; STEREOLITHOGRAPHY; TOPOGRAPHY; FILMS;

D O I：

10.1016/j.msec.2014.07.008

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The development of bioactive materials is in the premise of tissue engineering. For several years, surface functionalization of scaffolds has been one of the most promising approaches to stimulate cellular activity and finally improve implant success. Herein, we describe the development of a bioactive composite scaffold composed of a biodegradable photopolymer scaffold and titanate nanotubes (TNTs). The biodegradable photopolymer scaffolds were fabricated by applying mask-projection excimer laser photocuring at 308 nm.TNTs were synthesized and then spin-coated on the porous scaffolds. Upon culturing fibroblast cells on scaffolds, we found that nanotubes coating affects cell viability and proliferation demonstrating that TNT coatings enhance cell growth on the scaffolds by further improving their surface topography. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：38 / 43

页数：6

共 33 条

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