Were arachnids the first to use combinatorial peptide libraries?

被引：169

作者：

Sollod, BL

Wilson, D

Zhaxybayeva, O

Gogarten, JP

Drinkwater, R

King, GF

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Mol Microbial & Struct Biol, Farmington, CT 06032 USA

[2] Xenome Ltd, Indooroopilly, Qld 4068, Australia

[3] Univ Connecticut, Dept Mol & Cell Biol, Storrs, CT 06269 USA

来源：

PEPTIDES | 2005年 / 26卷 / 01期

关键词：

peptide toxin; toxin evolution; combinatorial peptide library; spider; scorpion; arachnid; cone snail; atracotoxin; conotoxin; prepropeptide; toxin precursor; cysteine scaffold;

D O I：

10.1016/j.peptides.2004.07.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spiders, scorpions, and cone snails are remarkable for the extent and diversity of gene-encoded peptide neurotoxins that are expressed in their venom glands. These toxins are produced in the form of structurally constrained combinatorial peptide libraries in which there is hypermutation of essentially all residues in the mature-toxin sequence with the exception of a handful of strictly conserved cysteines that direct the three-dimensional fold of the toxin. This gene-based combinatorial peptide library strategy appears to have been first implemented by arachnids almost 400 million years ago, long before cone snails evolved a similar mechanism for generating peptide diversity. (C) 2004 Elsevier Inc. All rights reserved.

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页码：131 / 139

页数：9

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