Synthesis and biological evaluation of (+)-labdadienedial, derivatives and precursors from (+)-sclareolide

被引：17

作者：

Gonzalez, Miguel A. ^{[1
]}

Mancebo-Aracil, Juan ^{[1
]}

Tangarife-Castano, Veronica ^{[2
]}

Agudelo-Gomez, Lee ^{[2
]}

Zapata, Bibiana ^{[2
]}

Mesa-Arango, Ana ^{[2
]}

Betancur-Galvis, Liliana ^{[2
]}

机构：

[1] Univ Valencia, Dept Quim Organ, E-46100 Valencia, Spain

[2] Univ Antioquia, Grp Bioact, Medellin 1226, Colombia

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 09期

关键词：

Labdane; Labdadienedial; Sclareolide; Cytotoxicity; Antimycotic; Antifungal; Antiviral; LABDANE DITERPENES; HEDYCHIUM-CORONARIUM; CYTOTOXIC ACTIVITY; CONSTITUENTS; RHIZOMES; (+)-GALANOLACTONE;

D O I：

10.1016/j.ejmech.2010.06.029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Labdadienedial and a series of C15,C16-functionalized derivatives were synthesized from commercial (+)-sclareolide and evaluated for their cytotoxic, antimycotic, and antiviral activities. Their precursors were similarly evaluated. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：4403 / 4408

页数：6

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