Molecular Architecture and Function of Matrix Adhesions

被引:377
作者
Geiger, Benjamin [1 ]
Yamada, Kenneth M. [2 ]
机构
[1] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel
[2] Natl Inst Craniofacial & Dent Res, Lab Cell & Dev Biol, NIH, Bethesda, MD 20892 USA
基金
以色列科学基金会; 美国国家卫生研究院;
关键词
EXTRACELLULAR-MATRIX; FOCAL ADHESIONS; NASCENT ADHESIONS; INTEGRIN FUNCTION; CONTACT FORMATION; CELL-SUBSTRATUM; GROWTH-FACTORS; ACTIN FLOW; DYNAMICS; FIBRONECTIN;
D O I
10.1101/cshperspect.a005033
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cell adhesions mediate important bidirectional interactions between cells and the extracellular matrix. They provide an interactive interface between the extracellular chemical and physical environment and the cellular scaffolding and signaling machinery. This dynamic, reciprocal regulation of intracellular processes and the matrix is mediated by membrane receptors such as the integrins, as well as many other components that comprise the adhesome. Adhesome constituents assemble themselves into different types of cell adhesion structures that vary in molecular complexity and change over time. These cell adhesions play crucial roles in cell migration, proliferation, and determination of cell fate.
引用
收藏
页码:1 / 21
页数:21
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