Challenges of probe cocktail approach for human drug-drug interaction assays

被引：3

作者：

Carrao, Daniel B. ^{[1
]}

de Oliveira, Anderson R. M. ^{[1
]}

Magalhaes, Igor R. S. ^{[2
]}

机构：

[1] Univ Sao Paulo, FFCLRP, Dept Quim, Lab Metab Vitro & Tecn Separacao, BR-14040901 Ribeirao Preto, Brazil

[2] Univ Fed Amazonas, UFAM, FCF, Nucleo Estudos Farmacocinet, BR-69077000 Manaus, Amazonas, Brazil

来源：

BIOANALYSIS | 2018年 / 10卷 / 24期

基金：

巴西圣保罗研究基金会;

关键词：

CYP450; drug-drug interaction; HLM; in vitro models; mass spectrometry; N-in-one; probe cocktail; HUMAN LIVER-MICROSOMES; IN-VITRO COCKTAIL; LIQUID-CHROMATOGRAPHY; CYTOCHROME-P450; ASSAY; INHIBITION; ENZYMES; VALIDATION;

D O I：

10.4155/bio-2018-0247

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：1969 / 1972

页数：4

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