Autocatalytic aerobic ipso-hydroxylation of arylboronic acid with Hantzsch ester and Hantzsch pyridine

被引：10

作者：

Fan, Chi-Hang ^{[1
,2
]}

Xu, Tianyue ^{[1
,2
]}

Ke, Zhihai ^{[3
]}

Yeung, Ying-Yeung ^{[1
,2
]}

机构：

[1] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, State Key Lab Synthet Chem, Shatin, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 15期

关键词：

ASYMMETRIC TRANSFER HYDROGENATION; OXIDATIVE HYDROXYLATION; ELECTRON-TRANSFER; METAL-FREE; CATALYZED HYDROXYLATION; PHOTOREDOX CATALYSIS; PHENOLS; ARYL; NANOPARTICLES; CONVERSION;

D O I：

10.1039/d2qo00618a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hantzsch esters are very useful hydrogen and electron donors that have been applied in many reactions. After the reactions, aromatic Hantzsch pyridines are generated as the by-products and their roles are commonly ignored. Herein, we report the use of Hantzsch pyridine as a promoter to activate Hantzsch ester in the generation of the hydrogen peroxy radical, which is useful for the ipso-hydroxylation of arylboronic acids to give phenols. The reaction does not require an external catalyst or light. The conditions are mild and highly compatible with different functional groups.

引用

页码：4091 / 4096

页数：6

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