Salternamides A-D from a Halophilic Streptomyces sp Actinobacterium

被引：36

作者：

Kim, Seong-Hwan ^{[1
]}

Shin, Yoonho ^{[1
]}

Lee, So-Hyoung ^{[2
]}

Oh, Ki-Bong ^{[2
]}

Lee, Sang Kook ^{[1
]}

Shin, Jongheon ^{[1
]}

Oh, Dong-Chan ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Nat Prod Res Inst, Seoul 151742, South Korea

[2] Seoul Natl Univ, Coll Agr & Life Sci, Dept Agr Biotechnol, Seoul 151921, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2015年 / 78卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

COUPLING-CONSTANTS; CONFIGURATION; HALOTOLERANT;

D O I：

10.1021/acs.jnatprod.5b00002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Salternamides A-D (1-4), the first secondary metabolites discovered from saltern-derived actinomycetes, were isolated from a halophilic Streptomyces strain isolated from a saltern on Shinui Island in the Republic of Korea. The planar structures of the salternamides, which are new members of the manumycin family, were elucidated by a combination of spectroscopic analyses. The absolute configurations of the salternamides were determined by chemical and spectroscopic methods, including the modified Moshers method, J-based configuration analysis, and circular dichroism spectroscopy. Salternamide A (1), which is the first chlorinated compound in the manumycin family, exhibited potent cytotoxicity against a human colon cancer cell line (HCT116) and a gastric cancer cell line (SNU638) with submicromolar IC50 values. Salternamides A and D were also determined to be weak Na+/K+ ATPase inhibitors.

引用

页码：836 / 843

页数：8

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