Charge-reversal biodegradable MSNs for tumor synergetic chemo/ photothermal and visualized therapy

被引：176

作者：

Li, Zimu ^{[1
]}

Yang, Yao ^{[1
]}

Wei, Huaxuan ^{[1
]}

Shan, Xiaoting ^{[1
]}

Wang, Xuanzhi ^{[1
]}

Ou, Meitong ^{[1
]}

Liu, Qingyun ^{[1
]}

Gao, Nansha ^{[1
]}

Chen, Hongzhong ^{[1
]}

Mei, Lin ^{[1
,2
]}

Zeng, Xiaowei ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Inst Pharmaceut, Shenzhen 518107, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Biomed Engn, Tianjin Key Lab Biomed Mat, Key Lab Biomed & Nanotechnol Canc Immunotherapy, Tianjin 300192, Peoples R China

来源：

JOURNAL OF CONTROLLED RELEASE | 2021年 / 338卷

基金：

中国国家自然科学基金;

关键词：

Nanomedicine; Charge-reversal; Biodegradation; Mesoporous silica; Tumor therapy; CO-DELIVERY; IN-VITRO; CANCER; CARRIER;

D O I：

10.1016/j.jconrel.2021.09.005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Given the difficulties of biodegradation of mesoporous silica nanoparticles (NPs), enrichment and penetration of tumor sites, and real-time monitoring of the treatment process, we developed a kind of mannose-doping doxorubicin-loading mesoporous silica nanoparticle (MSN-Man-DOX) and coated by polydopamine-Gd3+ (PDA-Gd) metal-phenolic networks, as well as modified by poly (2-Ethyl-2-Oxazoline) (PEOz), constructing a novel nanomedicine MSN-Man-DOX@PDA-Gd-PEOz. Its pH-responsive charge reversal, photothermal, biodegradation, drug release, and magnetic resonance imaging (MRI) properties were evaluated in vitro. Cellular uptake, tumor penetration, lysosomal escape properties, as well as cell safety and toxicity of the nanoplatform were investigated through cell experiments. Finally, the MRI, organ distribution, photothermal condition, and comprehensive antitumor therapy in vivo were evaluated comprehensively through animal experiments. Research results showed that MSN-Man-DOX@PDA-Gd-PEOz had outstanding tumor enrichment and penetration abilities, which can produce excellent treatment effects through the synergistic effect of chemotherapy and photothermal therapy (PTT) with the function of magnetic resonance imaging contrast agent for disease monitoring. Besides, after finishing the therapeutic effect MSN-Man-DOX@PDA-Gd-PEOz can be biodegraded, so it had a good prospect of clinical application.

引用

页码：719 / 730

页数：12

共 52 条

[1] Dopamine-Melanin Film Deposition Depends on the Used Oxidant and Buffer Solution [J].

Bernsmann, Falk ;

Ball, Vincent ;

Addiego, Frederic ;

Ponche, Arnaud ;

Michel, Marc ;

de Almeida Gracio, Jose Joaquin ;

Toniazzo, Valerie ;

Ruch, David .

LANGMUIR, 2011, 27 (06) :2819-2825

[2] Electrospun nanofibers for cancer diagnosis and therapy [J].

Chen, Zhou ;

Chen, Zhaofeng ;

Zhang, Aili ;

Hu, Jiaming ;

Wang, Xinmei ;

Yang, Zhaogang .

BIOMATERIALS SCIENCE, 2016, 4 (06) :922-932

[3] Versatile Polydopamine Platforms: Synthesis and Promising Applications for Surface Modification and Advanced Nanomedicine [J].

Cheng, Wei ;

Zeng, Xiaowei ;

Chen, Hongzhong ;

Li, Zimu ;

Zeng, Wenfeng ;

Mei, Lin ;

Zhao, Yanli .

ACS NANO, 2019, 13 (08) :8537-8565

[4] TPGS-Functionalized Polydopamine-Modified Mesoporous Silica as Drug Nanocarriers for Enhanced Lung Cancer Chemotherapy against Multidrug Resistance [J].

Cheng, Wei ;

Liang, Chaoyu ;

Xu, Lv ;

Liu, Gan ;

Gao, Nansha ;

Tao, Wei ;

Luo, Lingyan ;

Zuo, Yixiong ;

Wang, Xusheng ;

Zhang, Xudong ;

Zeng, Xiaowei ;

Mei, Lin .

SMALL, 2017, 13 (29)

[5] pH-Sensitive Delivery Vehicle Based on Folic Acid-Conjugated Polydopamine-Modified Mesoporous Silica Nanoparticles for Targeted Cancer Therapy [J].

Cheng, Wei ;

Nie, Junpeng ;

Xu, Lv ;

Liang, Chaoyu ;

Peng, Yunmei ;

Liu, Gan ;

Wang, Teng ;

Mei, Lin ;

Huang, Laiqiang ;

Zeng, Xiaowei .

ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (22) :18462-18473

[6] Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles [J].

Croissant, Jonas G. ;

Fatieiev, Yevhen ;

Khashab, Niveen M. .

ADVANCED MATERIALS, 2017, 29 (09)

[7] Nanoparticle-based drug delivery systems for cancer therapy [J].

Dang Y. ;

Guan J. .

Smart Materials in Medicine, 2020, 1 :10-19

[8] Engineering Fluorescent Gold Nanoclusters Using Xanthate-Functionalized Hydrophilic Polymers: Toward Enhanced Monodispersity and Stability [J].

Deepagan, Veerasikku Gopal ;

Leiske, Meike N. ;

Fletcher, Nicholas L. ;

Rudd, David ;

Tieu, Terence ;

Kirkwood, Nicholas ;

Thurecht, Kristofer J. ;

Kempe, Kristian ;

Voelcker, Nicolas H. ;

Cifuentes-Rius, Anna .

NANO LETTERS, 2021, 21 (01) :476-484

[9] Metal-phenolic networks as a versatile platform to engineer nanomaterials and biointerfaces [J].

Ejima, Hirotaka ;

Richardson, Joseph J. ;

Caruso, Frank .

NANO TODAY, 2017, 12 :136-148

[10] pH-Responsive Dual Drug-Loaded Nanocarriers Based on Poly (2-Ethyl-2-Oxazoline) Modified Black Phosphorus Nanosheets for Cancer Chemo/Photothermal Therapy [J].

Gao, Nansha ;

Xing, Chenyang ;

Wang, Haifei ;

Feng, Liwen ;

Zeng, Xiaowei ;

Mei, Lin ;

Peng, Zhengchun .

FRONTIERS IN PHARMACOLOGY, 2019, 10

← 1 2 3 4 5 6 →