Synthesis of a non-peptide analogue of omega-conotoxin MVIIA

被引：30

作者：

Menzler, S ^{[1
]}

Bikker, JA ^{[1
]}

Horwell, DC ^{[1
]}

机构：

[1] Parke Davis Neurosci Res Ctr, Cambridge CB2 2QB, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 41期

关键词：

amidines; oxadiazoles; peptide analogues; phenols; N-type neuronal calcium channels;

D O I：

10.1016/S0040-4039(98)01657-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of an alkylphenyl ether based peptidomimetic is described. The compound mimics three key amino acids of omega-conotoxin MVIIA from the cone shell Conus magus and may provide an entry to the design of low molecular weight antagonists of N-type neuronal calcium channels. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7619 / 7622

页数：4

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