Enantioselective organocatalytic transfer hydrogenation reactions using Hantzsch esters

被引：466

作者：

Ouellet, Stephane G. ^{[2
]}

Walji, Abbas M. ^{[1
]}

Macmillan, David W. C. ^{[1
]}

机构：

[1] Princeton Univ, Merck Ctr Catalysis, Princeton, NJ 08544 USA

[2] Merck Frosst Ctr Therapeut Res, Dept Proc Res, Kirkland, PQ H9H 3L1, Canada

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2007年 / 40卷 / 12期

关键词：

D O I：

10.1021/ar7001864

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Within the realm of catalytic asymmetric hydrogenation, the focus continues to be on the use of chiral metal complexes in conjunction with a hydrogen Source. Recently, the widespread development of organocatalysis, including the invention of iminium activation, has led to the discovery of many new enantioselective transformations. Based on this strategy, a number of bioinspired processes for the enantioselective organocatalytic transfer hydrogenation of alpha,beta-unsaturated carbonyl Compounds and imines have been discovered. These topics will be the focus of this Account.

引用

页码：1327 / 1339

页数：13

共 51 条

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