Fast regioselective sulfonylation of pyridine/quinoline N-oxides induced by iodine

被引：53
|
作者：
Wang, Ruijia [1 ,2 ]
Zeng, Zebing [1 ]
Chen, Chuang [1 ]
Yi, Niannian [1 ]
Jiang, Jun [1 ]
Cao, Zhong [2 ]
Deng, Wei [1 ]
Xiang, Jiannan [1 ]
机构：
[1] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China
[2] Changsha Univ Sci & Technol, Sch Chem & Biol Engn, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410004, Hunan, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 23期
基金：
中国国家自然科学基金;
关键词：
H BOND FUNCTIONALIZATION; QUINOLINE; QUINAZOLINE; AMINATION; CHLORIDES; ACID;
D O I：
10.1039/c6ob00925e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Fast sulfonylation of pyridine/quinoline N-oxides induced by iodine is demonstrated herein. The regioselective protocol occurs under metal-free conditions in a short reaction time (10 min), exhibiting high efficiency (up to 92% yield) and good compatibility (up to 33 examples). A gram-scale reaction was conducted with only a slight loss of production.
引用
收藏
页码：5317 / 5321
页数：5
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