Ex-vivo liver perfusion for organ preservation: Recent advances in the field

被引：27
作者：
Barbas, A. S. [1 ]
Goldaracena, N. [1 ]
Dib, M. J. [1 ]
Selzner, M. [1 ]
机构：
[1] Univ Toronto, Multiorgan Transplant Program, Dept Surg, Toronto, ON M5S 1A1, Canada
来源：
TRANSPLANTATION REVIEWS | 2016年 / 30卷 / 03期
关键词：
SUBNORMOTHERMIC MACHINE PERFUSION; BILE-DUCT INJURY; COLD-STORAGE; ISCHEMIA/REPERFUSION INJURY; REWARMING PRESERVATION; STEATOTIC LIVERS; HOPE PROTECTS; DONOR LIVERS; TRANSPLANTATION; DONATION;
D O I：
10.1016/j.trre.2016.03.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Liver transplantation is the optimal treatment for end-stage liver disease but is limited by the severe shortage of donor organs. This shortage has prompted increased utilization of marginal grafts from DCD and extended criteria donors, which poorly tolerate cold storage in comparison to standard criteria grafts. Ex-vivo liver perfusion (EVLP) technology has emerged as a potential alternative to cold storage for organ preservation, but there is no consensus regarding the optimal temperature or conditions for EVLP. Herein, we review recent advances in both pre-clinical and clinical studies, organized by perfusion temperature (hypothermic, subnormothermic, normothermic). (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：154 / 160
页数：7
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