Effects of Mulberry Leaf Extract Rich in 1-Deoxynojirimycin on Blood Lipid Profiles in Humans

被引：88

作者：

Kojima, Yoshihiro ^{[1
,2
]}

Kimura, Toshiyuki ^{[3
]}

Nakagawa, Kiyotaka ^{[4
]}

Asai, Akira ^{[5
]}

Hasumi, Keiji ^{[1
]}

Oikawa, Shinichi ^{[5
]}

Miyazawa, Teruo ^{[4
]}

机构：

[1] Tokyo Univ Agr & Technol, United Grad Sch Agr Sci, Tokyo 1838538, Japan

[2] Minato Pharmaceut Co Ltd, Chuo Ku, Tokyo 1040061, Japan

[3] Natl Agr Res Ctr Tohoku Reg, Fukushima 9602156, Japan

[4] Tohoku Univ, Grad Sch Agr Sci, Food & Biodynam Chem Lab, Sendai, Miyagi 9818555, Japan

[5] Nippon Med Sch, Dept Med, Tokyo 1138603, Japan

来源：

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2010年 / 47卷 / 02期

关键词：

1-deoxynojirimycin; mulberry leaf extract; serum triglyceride; serum lipid profile; LEAVES; CHROMATOGRAPHY; LIPOPROTEIN; CHOLESTEROL;

D O I：

10.3164/jcbn.10-53

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Mulberry leaves are rich in 1-deoxynojirimycin (DNJ), an inhibitor of a-glucosidase. We previously showed that DNJ-rich mulberry leaf extract suppressed elevation of postprandial blood glucose in humans. The objective of this study was to evaluate the effects of DNJ-rich mulberry leaf extract on plasma lipid profiles in humans. An open-label, single-group study was conducted in 10 subjects with initial serum triglyceride (TG) level >= 200 mg/dl. Subjects ingested capsules containing DNJ-rich mulberry leaf extract at 12 mg three times daily before meals for 12 weeks. Our findings showed a modest decrease in serum TG level and beneficial changes in the lipoprotein profile following 12-week administration of DNJ-rich mulberry leaf extract. No significant changes in hematological or biochemical parameters were observed during the study period; no adverse events associated with DNJ-rich mulberry leaf extract occurred.

引用

页码：155 / 161

页数：7

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