Cardiovascular disease biomarkers in patients with inborn errors of protein metabolism: a pilot study

被引:8
作者
Karam, P. E. [1 ]
Majdalani, M. N. [1 ]
Daher, R. T. [2 ]
Barhoumi, A. [3 ]
Yazbeck, N. [1 ]
机构
[1] Amer Univ Beirut, Dept Pediat & Adolescent Med, Med Ctr, Beirut 11072020, Lebanon
[2] Amer Univ Beirut, Dept Pathol & Lab Med, Med Ctr, Beirut 11072020, Lebanon
[3] Amer Univ Beirut, Dept Nutr, Med Ctr, Beirut 11072020, Lebanon
关键词
homocysteine; lipids; low-protein diet; mediterranean diet; PHENYLKETONURIC CHILDREN; LIPID CONCENTRATIONS; DIET; ADULTS; SERUM; PHENYLALANINE; ADOLESCENTS; CHOLESTEROL; PROFILE; RISK;
D O I
10.1111/jhn.12255
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
BackgroundLimited data exist so far on cardiovascular disease biomarkers in patients maintained on a protein-restricted diet for inborn errors of protein metabolism. The present study aimed to analyse plasma cholesterol, lipoproteins, triglycerides and total homocysteine in patients with various inborn errors of protein metabolism in comparison with healthy controls. MethodsA cross-sectional study of cardiovascular disease biomarkers was conducted in a cohort of patients with inborn errors of protein metabolism: nine phenylketonuria, nine urea cycle defect, six branched chain organic acidaemia and two tyrosinaemia type I patients compared to 30 healthy controls. All patients were on a strict natural protein diet for a mean (SD) period of 5.37(2.30)years (range 2-9years). Dietary assessment, plasma cholesterol, triglycerides, lipoproteins and total homocysteine levels were obtained. ResultsThere were no significant differences in blood lipid studies and total homocysteine levels between patients and controls. ConclusionsThe results obtained in this pilot study suggest that cardiovascular disease biomarkers are not increased in patients with inborn errors of protein metabolism. This may be explained by the possible protective effect of a mono- and polyunsaturated fat rich Mediterranean diet. Additional studies with a larger number of patients are needed to confirm this finding.
引用
收藏
页码:344 / 349
页数:6
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